Disseminated fusariosis and endogenous fungal endophthalmitis in acute lymphoblastic leukemia following platelet transfusion possibly due to transfusion-related immunomodulation

BMC Ophthalmology

Case Report

Tan Aik Kah¹  Ku Chui Yong²  Ropilah Abdul Rahman² 

[1] Department of Ophthalmology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak (UNIMAS), Jalan Tun Ahmad Zaidi Adruce, Lot 77, Seksyen 22, Kuching Town Land District, 93150, Kuching, Sarawak, Malaysia;Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC) Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia;Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC) Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia;

关键词: Acute Lymphoblastic Leukemia;    Endophthalmitis;    Platelet Transfusion;    Activate Partial Thromboplastin Time;    Final Visual Acuity;   

DOI  :  10.1186/1471-2415-11-30

 received in 2011-03-29, accepted in 2011-11-02,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTo report a case of disseminated fusariosis with endogenous endophthalmitis in a patient with acute lymphoblastic leukemia. Transfusion-associated immune modulation secondary to platelet transfusion could play an important role in the pathophysiology of this case.Case PresentationA 9 year-old male with acute lymphoblastic leukemia complicated by pancytopenia and disseminated Intravascular coagulation was given platelet transfusion. He developed disseminated fusariosis and was referred to the ophthalmology team for right endogenous endophthalmitis. The infection was controlled with aggressive systemic and intravitreal antifungals.ConclusionPatients with acute lymphoblastic leukemia are predisposed to endogenous fungal endophthalmitis. Transfusion-associated immune modulation may further increase host susceptibility to such opportunistic infections.

【 授权许可】

CC BY   
© Kah et al; licensee BioMed Central Ltd. 2011