The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort

BMC Pregnancy and Childbirth

Research Article

Eero Kajantie¹  Juha Kere²  Katja Kivinen³  Jenni Kallela⁴  Eija Kortelainen⁴  Tiina Jääskeläinen⁴  Hannele Laivuori⁵  Seppo Heinonen⁶  Anneli Pouta⁷ 

[1] Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland;Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;Department of Biosciences and Nutrition, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden;Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland;Folkhälsan Institute of Genetics, Helsinki, Finland;Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK;Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;Department of Government services, National Institute for Health and Welfare, Helsinki, Finland;

关键词: Pre-eclampsia;    Gestational hypertension;    Proteinuria;    Classification;    Criteria;   

DOI  :  10.1186/s12884-016-1010-0

 received in 2016-05-14, accepted in 2016-08-03,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe Finnish Pre-eclampsia Consortium (FINNPEC) case-control cohort consisting of 1447 pre-eclamptic and 1068 non-pre-eclamptic women was recruited during 2008–2011 to study genetic background of pre-eclampsia and foetal growth. Pre-eclampsia was defined by hypertension and proteinuria according to the American College of Obstetricians and Gynecologists (ACOG) 2002 classification. The ACOG Task Force Report on Hypertension in Pregnancy (2013) and The International Society for the Study of Hypertension in Pregnancy (ISSHP) (2014) have published new classifications, in which proteinuria is not necessary for diagnosis when specific symptoms are present. For diagnoses based on proteinuria, the ISSHP 2014 criteria raised its threshold to 2+ on dipstick. We studied how the new classifications would affect pre-eclampsia diagnoses in the FINNPEC cohort.MethodsWe re-evaluated pre-eclampsia diagnosis using the ACOG 2013 and the ISSHP 2014 classifications in pre-eclamptic women whose proteinuria did not exceed 1+ on dipstick (n = 68), in women with gestational hypertension (n = 138) and in women with chronic hypertension (n = 66).ResultsThe number of women with pre-eclampsia increased 0.8 % (1459/1447) according to the ACOG 2013 criteria and 0.6 % (1455/1447) according to the ISSHP 2014 criteria. All 68 women with the amount of proteinuria not exceeding 1+ on dipstick diagnosed originally pre-eclamptic met the ACOG 2013 criteria but only 20 women (29.4 %) met the ISSHP 2014 criteria. Seven (5.1 %) and 35 (25.4 %) women with gestational hypertension were diagnosed with pre-eclampsia according to the ACOG 2013 and the ISSHP 2014 criteria, respectively. Correspondingly five (7.6 %) and 21 (31.8 %) women with chronic hypertension were diagnosed with pre-eclampsia according to the ACOG 2 013 and the ISSHP 2014 criteria.ConclusionsOnly minor changes were observed in the total number of pre-eclamptic women in the FINNPEC cohort when comparing the ACOC 2002 classification with the ACOG 2013 and ISSHP 2014 classifications.

【 授权许可】

CC BY   
© The Author(s). 2016