Adjuvant glycerol is not beneficial in experimental pneumococcal meningitis

BMC Infectious Diseases

Research Article

Matthias Klein¹  Uwe Koedel¹  Heikki Peltola²  Denis Grandgirard³  Cornelia Blaser³  Matthias Wittwer³  Stephen L Leib³  Michael Weigand⁴ 

[1] Department of Neurology, Klinikum Großhadern, Ludwig-Maximilians University, 81377, Munich, Germany;The Meningitis Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EMESG), Switzerland;Helsinki University Central Hospital, Hospital for Children and Adolescents, 00029 HUSHelsinki, Finland;The Meningitis Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EMESG), Switzerland;Institute for Infectious Diseases, University of Bern, 3010, Bern, Switzerland;The Meningitis Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EMESG), Switzerland;Institute of Clinical Chemistry, Klinikum Großhadern, Ludwig-Maximilians University, 81377, Munich, Germany;

关键词: Hearing Loss;    Bacterial Meningitis;    Auditory Brainstem Response;    Hearing Threshold;    Pneumococcal Meningitis;   

DOI  :  10.1186/1471-2334-10-84

 received in 2010-01-07, accepted in 2010-03-30,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundBacterial meningitis in children causes high rates of mortality and morbidity. In a recent clinical trial, oral glycerol significantly reduced severe neurological sequelae in paediatric meningitis caused by Haemophilus influenzae type b, and a tendency towards a benefit of adjunctive glycerol was seen in pneumococcal meningitis.MethodsHere we examined the effects of glycerol in pneumococcal meningitis of infant rats and adult mice. All animals received ceftriaxone, and glycerol or placebo. Brain damage, hearing loss, and inflammatory parameters were assessed.ResultsClinically and by histopathology, animals treated with glycerol or placebo did not differ. While both groups showed equally high levels of matrix metalloproteinase-9 at 24 h after infection, a significant difference in favour of glycerol was observed at 40 h after infection. However, this difference in matrix metalloproteinase-9 in late disease did not result in an improvement of histopathologic parameters.ConclusionNo benefit of adjunctive glycerol was found in these models of pneumococcal meningitis.

【 授权许可】

Unknown   
© Blaser et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.