Genetic testing for exercise prescription and injury prevention: AIS-Athlome consortium-FIMS joint statement

BMC Genomics

Review

Nicole Vlahovich¹  David C. Hughes²  Fabio Pigozzi³  Lyn R. Griffiths⁴  Nir Eynon⁵  Nobert Bachl⁶  Guan Wang⁷  Yannis P. Pitsiladis⁸ 

[1] Australian Institute of Sport (AIS), Australian Sports Commission, Canberra, Australia;Australian Institute of Sport (AIS), Australian Sports Commission, Canberra, Australia;University of Canberra Research Institute for Sport and Exercise (UCRISE), University of Canberra, Canberra, Australia;Department of Movement Human and Health Sciences University of Rome “Foro Italico”, Rome, Italy;International Federation of Sports Medicine (FIMS), Lausanne, Switzerland;Genomics Research Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, Brisbane, Australia;Institute of Sport, Exercise and Active Living (ISEAL), College of Sport and Exercise Science, Victoria University, PO Box 14428, 8001, Melbourne, VIC, Australia;International Federation of Sports Medicine (FIMS), Lausanne, Switzerland;Department of Sports and Exercise Physiology, Centre for Sports Science and University Sports of the University of Vienna, Vienna, Austria;Reference Collaborating Centre of Sports Medicine for Anti-Doping Research, University of Brighton, Eastbourne, UK;Reference Collaborating Centre of Sports Medicine for Anti-Doping Research, University of Brighton, Eastbourne, UK;Department of Movement Human and Health Sciences University of Rome “Foro Italico”, Rome, Italy;International Federation of Sports Medicine (FIMS), Lausanne, Switzerland;

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DOI  :  10.1186/s12864-017-4185-5

来源: Springer

【 摘 要 】

BackgroundThere has been considerable growth in basic knowledge and understanding of how genes are influencing response to exercise training and predisposition to injuries and chronic diseases. On the basis of this knowledge, clinical genetic tests may in the future allow the personalisation and optimisation of physical activity, thus providing an avenue for increased efficiency of exercise prescription for health and disease.ResultsThis review provides an overview of the current status of genetic testing for the purposes of exercise prescription and injury prevention. As such there are a variety of potential uses for genetic testing, including identification of risks associated with participation in sport and understanding individual response to particular types of exercise. However, there are many challenges remaining before genetic testing has evidence-based practical applications; including adoption of international standards for genomics research, as well as resistance against the agendas driven by direct-to-consumer genetic testing companies. Here we propose a way forward to develop an evidence-based approach to support genetic testing for exercise prescription and injury prevention.ConclusionBased on current knowledge, there is no current clinical application for genetic testing in the area of exercise prescription and injury prevention, however the necessary steps are outlined for the development of evidence-based clinical applications involving genetic testing.

【 授权许可】

CC BY   
© The Author(s). 2017