Matrix metalloproteinase-9gene polymorphisms in nasal polyposis

BMC Medical Genetics

Research Article

Suh-Hang Hank Juo¹  Wen-Rei Kuo²  Chih-Feng Tai²  Ling-Feng Wang³  Edward Hsi⁴  Chen-Yu Chien⁵ 

[1] Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Department of Otolaryngology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Otolaryngology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Department of Otolaryngology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Otolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Otolaryngology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Otolaryngology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;

关键词: Nasal Polyp;    Chronic Rhinosinusitis;    Nasal Polyposis;    TaqMan Minor Groove Binder;    TaqMan Minor Groove;   

DOI  :  10.1186/1471-2350-11-85

 received in 2009-09-17, accepted in 2010-06-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundMatrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that genetic variants of the MMP-9 gene are associated with cases of chronic rhinosinusitis with nasal polyposis.MethodsWe conducted a case-control study where 203 cases of chronic rhinosinusitis with nasal polyposis and 730 controls were enrolled. Three tagging single nucleotide polymorphisms (SNPs) and one promoter functional SNP rs3918242 were selected. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. Haplotype analysis was also performed. Permutation was used to adjust for multiple testing.ResultsAll four SNPs were in HWE. The T allele of promoter SNP rs3918242 was associated with chronic rhinosinusitis with nasal polyposis under the dominant (nominal p = 0.023, empirical p = 0.022, OR = 1.62) and additive models (nominal p= 0.012, empirical p = 0.011, OR = 1.60). The A allele of rs2274756 has a nominal p value of 0.034 under the dominant model and 0.020 under the additive model. Haplotype analysis including the four SNPs showed a global p value of 0.015 and the most significant haplotype had a p value of 0.0045. We did not see any SNP that was more significant in the recurrent cases.ConclusionsWe concluded that MMP-9 gene polymorphisms may influence susceptibility to the development of chronic rhinosinusitis with nasal polyposis in Chinese population.

【 授权许可】

Unknown   
© Wang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.