Combined association of chronic disease and low skeletal muscle mass with physical performance in older adults in the Sarcopenia and Translational Aging Research in Taiwan (START) study

BMC Geriatrics

Research Article

Chih-Hsing Wu¹  Kuo-Chin Huang²  Chia-Ing Li³  Tsai-Chung Li⁴  Chao A Hsiung⁵  Ching-Yu Chen⁶  Chih-Cheng Hsu⁷  Wen-Yuan Lin⁸  Chiu-Shong Liu⁸  Cheng-Chieh Lin⁹  Ching-Yi Wang^1,10 

[1] Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan;Department of Family Medicine, National Taiwan University, Taipei, Taiwan;Department of Medical Research, China Medical University Hospital, Taichung, Taiwan;School of Medicine, China Medical University, 91 Hsueh-Shih Road, 40421, Taichung, Taiwan;Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung, Taiwan;Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan;Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan;Department of Family Medicine, National Taiwan University, Taipei, Taiwan;Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan;Department of Health Services Administration, China Medical University, Taichung, Taiwan;School of Medicine, China Medical University, 91 Hsueh-Shih Road, 40421, Taichung, Taiwan;Department of Family Medicine, China Medical University Hospital, Taipei, Taiwan;School of Medicine, China Medical University, 91 Hsueh-Shih Road, 40421, Taichung, Taiwan;Department of Family Medicine, China Medical University Hospital, Taipei, Taiwan;Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan;School of Physical Therapy & Center for Education and Research on Geriatrics and Gerontology, Chung Shan Medical University, Taichung, Taiwan;

关键词: Chronic disease;    Low muscle mass;    Physical performance;   

DOI  :  10.1186/s12877-015-0011-6

 received in 2014-08-26, accepted in 2015-02-04,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMultiple chronic conditions and low skeletal muscle mass are common features of aging that are detrimental to physical performance. This study evaluates the simultaneous impact of these conditions on physical performance in older adults.MethodsFive studies from 2003 to 2012 were pooled to include 2,398 adults aged ≥65 years with diagnosed chronic diseases measured by self-administered questionnaire. Low muscle mass was defined as an appendicular skeletal muscle mass index less than that of the sex-specific lowest quintile in the population of older adults. Poor physical performances were defined as the lowest quintile of grip strength and gait speed in the population of older adults and the slowest sex-specific 20% of Timed Up and Go (TUG) test at each study site. Chi-squared and logistic regression tests were applied for data analysis.ResultsMean age of the study participants, of whom approximately 50% were men, was 74.3 years. Slow gait speed was nearly three times more likely to occur in the presence of low muscle mass coupled with chronic disease than in the absence of both factors after adjustment for study site, age, sex, education, marital status, body mass index, tobacco and alcohol use, and comorbidities. The independent effect of low muscle mass was generally stronger than that of each disease. Participants with more than two chronic diseases and low muscle mass were significantly more likely to perform poorly than those with no risk factors (odds ratio [OR] = 2.51 in patients with low grip strength, OR = 3.89 in patients with low gait speed, and OR = 3.67 in patients with poor TUG test scores, all P < 0 .05) after adjustment.ConclusionsThe combined association of chronic disease and low skeletal mass with physical performance was stronger than the effect of either factor alone.

【 授权许可】

Unknown   
© Li et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.