Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats

BMC Neuroscience

Research Article

Fauziah Othman¹  Sharmili Vidyadaran²  Toktam Hajjar³  Mohamed A Rajion³  Mahdi Ebrahimi³  Tan A Li³  Goh Y Meng⁴  Abdoreza S Farjam⁴ 

[1] Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia;Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia;Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia;Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia;Institute of Tropical Agriculture, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia;

关键词: PUFA;    n-6: n-3 PUFA ratio;    Spatial learning;    PPAR;    Cognitive function;   

DOI  :  10.1186/1471-2202-13-109

 received in 2012-04-07, accepted in 2012-09-14,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThis study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague–Dawley rats were randomly allotted into 3 groups of ten animals each and received experimental diets with different n-6: n-3 PUFA ratios of either 65:1, 22:1 or 4.5:1. After 10 weeks, the spatial memory of the animals was assessed using the Morris Water Maze test. The expression of PPARα and PPARγ genes were determined using real-time PCR.ResultsDecreasing dietary n-6: n-3 PUFA ratios improved the cognitive performance of animals in the Morris water maze test along with the upregulation of PPARα and PPARγ gene expression. The animals with the lowest dietary n-6: n-3 PUFA ratio presented the highest spatial learning improvement and PPAR gene expression.ConclusionIt can be concluded that modulation of n-6: n-3 PUFA ratios in the diet may lead to increased hippocampal PPAR gene expression and consequently improved spatial learning and memory in rats.

【 授权许可】

Unknown   
© Hajar et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.