An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited

BMC Medical Imaging

Software

Frank G. Zöllner¹  Lothar R. Schad¹  Markus Daab¹  Gerald Weisser²  Stefan O. Schoenberg²  Steven P. Sourbron³ 

[1] Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany;Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany;Division of Biomedical Imaging, University of Leeds, Leeds, UK;

关键词: Open source software;    Dce-mri;    Data analysis;    Compartment models;    Workflow;   

DOI  :  10.1186/s12880-016-0109-0

 received in 2015-08-21, accepted in 2016-01-06,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPerfusion imaging has become an important image based tool to derive the physiological information in various applications, like tumor diagnostics and therapy, stroke, (cardio-) vascular diseases, or functional assessment of organs. However, even after 20 years of intense research in this field, perfusion imaging still remains a research tool without a broad clinical usage. One problem is the lack of standardization in technical aspects which have to be considered for successful quantitative evaluation; the second problem is a lack of tools that allow a direct integration into the diagnostic workflow in radiology.ResultsFive compartment models, namely, a one compartment model (1CP), a two compartment exchange (2CXM), a two compartment uptake model (2CUM), a two compartment filtration model (2FM) and eventually the extended Toft’s model (ETM) were implemented as plugin for the DICOM workstation OsiriX. Moreover, the plugin has a clean graphical user interface and provides means for quality management during the perfusion data analysis. Based on reference test data, the implementation was validated against a reference implementation. No differences were found in the calculated parameters.ConclusionWe developed open source software to analyse DCE-MRI perfusion data. The software is designed as plugin for the DICOM Workstation OsiriX. It features a clean GUI and provides a simple workflow for data analysis while it could also be seen as a toolbox providing an implementation of several recent compartment models to be applied in research tasks. Integration into the infrastructure of a radiology department is given via OsiriX. Results can be saved automatically and reports generated automatically during data analysis ensure certain quality control.

【 授权许可】

CC BY   
© Zöllner et al. 2016