BMC Psychiatry | |
Residual symptoms and functioning in depression, does the type of residual symptom matter? A post-hoc analysis | |
Research Article | |
Inmaculada Gilaberte1  Antonio Ciudad1  Pepa Polavieja1  Irene Romera2  Luis Caballero3  Víctor Pérez4  Miguel Roca5  | |
[1] Department of Clinical Research Lilly, S.A. Avenida de la Industria 30, 28108, Alcobendas, Spain;Department of Clinical Research Lilly, S.A. Avenida de la Industria 30, 28108, Alcobendas, Spain;Autonomous University of Barcelona, Barcelona, Spain;Department of Psychiatry, Hospital Puerta de Hierro, Madrid, Spain;Department of Psychiatry, Hospital Santa Creu i Sant Pau, Autonomous University of Barcelona / CIBERSAM, Barcelona, Spain;Department of Psychiatry, Joan March Hospital, Rediapp, Palma de Mallorca, Spain; | |
关键词: Residual symptoms; Major depression; Functioning; | |
DOI : 10.1186/1471-244X-13-51 | |
received in 2013-01-23, accepted in 2013-01-30, 发布年份 2013 | |
来源: Springer | |
【 摘 要 】
BackgroundThe degrees to which residual symptoms in major depressive disorder (MDD) adversely affect patient functioning is not known. This post-hoc analysis explored the association between different residual symptoms and patient functioning.MethodsPatients with MDD who responded (≥50% on the 17-item Hamilton Rating Scale for Depression; HAMD-17) after 3 months of treatment (624/930) were included. Residual core mood-symptoms (HAMD-17 core symptom subscale ≥1), residual insomnia-symptoms (HAMD-17 sleep subscale ≥1), residual anxiety-symptoms (HAMD-17-anxiety subscale ≥1), residual somatic-symptoms (HAMD-17 Item 13 ≥1), pain (Visual Analogue Scale ≥30), and functioning were assessed after 3 months treatment. A stepwise logistic regression model with normal functioning (Social and Occupational Functioning Assessment Scale ≥80) as the dependent variable was used.ResultsAfter 3 months, 59.5% of patients (371/624) achieved normal functioning and 66.0% (412/624) were in remission. Residual symptom prevalence was: core mood symptoms 72%; insomnia 63%; anxiety 78%; and somatic symptoms 41%. Pain reported in 18%. Factors associated with normal functioning were absence of core mood symptoms (odds ratio [OR] 8.7; 95% confidence interval [CI], 4.6–16.7), absence of insomnia symptoms (OR 1.8; 95% CI, 1.2–2.7), episode length (4–24 weeks vs. ≥24 weeks [OR 2.0; 95% CI, 1.1–3.6]) and better baseline functioning (OR 1.0; 95% CI, 1.0–1.1). A significant interaction between residual anxiety symptoms and pain was found (p = 0.0080).ConclusionsDifferent residual symptoms are associated to different degrees with patient functioning. To achieve normal functioning, specific residual symptoms domains might be targeted for treatment.
【 授权许可】
CC BY
© Romera et al.; licensee BioMed Central Ltd. 2013
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202311096582903ZK.pdf | 306KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]