Childbirth and consequent atopic disease: emerging evidence on epigenetic effects based on the hygiene and EPIIC hypotheses

BMC Pregnancy and Childbirth

Debate

H. G. Dahlen¹  S. Downe²  H. P. Kennedy³  M. L. Wright³  J. Y. Taylor³ 

[1] School of Nursing and Midwifery, Western Sydney University, Locked Bag 1797, 2751, Penrith, NSW, Australia;University of Central Lancashire, PR3 2LE, Preston, Lancashire, UK;Yale School of Nursing, 400 West Campus Drive, 06516, West Haven, CT, USA;

关键词: Epigenetics;    Birth;    Caesarean section;    Syntocinon;    Microbiome;    Antibiotics;   

DOI  :  10.1186/s12884-015-0768-9

 received in 2014-11-20, accepted in 2015-12-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundIn most high and middle income countries across the world, at least 1:4 women give birth by cesarean section. Rates of labour induction and augmentation are rising steeply; and in some countries up to 50 % of laboring women and newborns are given antibiotics. Governments and international agencies are increasingly concerned about the clinical, economic and psychosocial effects of these interventions.DiscussionThere is emerging evidence that certain intrapartum and early neonatal interventions might affect the neonatal immune response in the longer term, and perhaps trans-generationally. Two theories lead the debate in this area. Those aligned with the hygiene (or ‘Old Friends’) hypothesis have examined the effect of gut microbiome colonization secondary to mode of birth and intrapartum/neonatal pharmacological interventions on immune response and epigenetic phenomena. Those working with the EPIIC (Epigenetic Impact of Childbirth) hypothesis are concerned with the effects of eustress and dys-stress on the epigenome, secondary to mode of birth and labour interventions.SummaryThis paper examines the current and emerging findings relating to childbirth and atopic/autoimmune disease from the perspective of both theories, and proposes an alliance of research effort. This is likely to accelerate the discovery of important findings arising from both approaches, and to maximize the timely understanding of the longer-term consequences of childbirth practices.

【 授权许可】

CC BY   
© Dahlen et al. 2016