‘Third wave’ cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial

BMC Psychiatry

Study Protocol

Christian Gluud¹  Per Winkel¹  Theis Lange²  Mickey Kongerslev³  Erik Simonsen³  Janus Christian Jakobsen⁴  Per Sørensen⁵  Ulf Søgaard⁶  Kirsten Aaskov Larsen⁶ 

[1] Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Department 3344, Copenhagen, Rigshospitalet, Denmark;Department of Public Health, University of Copenhagen, Copenhagen, Denmark;Psychiatric Research Unit, Copenhagen University Hospital and Region Zealand, Roskilde, Denmark;Psychiatric Research Unit, Copenhagen University Hospital and Region Zealand, Roskilde, Denmark;Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Department 3344, Copenhagen, Rigshospitalet, Denmark;Psychiatric clinic, Bispebjerg, Psychiatry, Denmark;Psychiatric clinic, Roskilde, Psychiatry, Denmark;

关键词: Personality Disorder;    Major Depressive Disorder;    Cognitive Therapy;    Trial Participant;    Borderline Personality Disorder;   

DOI  :  10.1186/1471-244X-12-232

 received in 2012-06-24, accepted in 2012-12-13,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundMost interventions for depression have shown small or no effects. ‘Third wave‘ cognitive therapy and mentalization-based therapy have both gained some ground as treatments of psychological problems. No randomised trial has compared the effects of these two interventions for patients with major depression.Methods/ designWe plan a randomised, parallel group, assessor-blinded superiority clinical trial. During two years we will include 84 consecutive adult participants diagnosed with major depressive disorder. The participants will be randomised to either ‘third wave‘ cognitive therapy versus mentalization-based therapy. The primary outcome will be the Hamilton Rating Scale for Depression at cessation of treatment at 18 weeks. Secondary outcomes will be the proportion of patients with remission, Symptom Checklist 90 Revised, Beck’s Depression Inventory, and The World Health Organisation-Five Well-being Index 1999.DiscussionInterventions for depression have until now shown relatively small effects. Our trial results will provide knowledge about the effects of two modern psychotherapeutic interventions.Trial registrationClinicalTrials: NCT01070134

【 授权许可】

CC BY   
© Jakobsen et al.; licensee BioMed Central Ltd. 2012