Design of a dietary intervention to assess the impact of a gluten-free diet in a population with type 1 Diabetes and Celiac Disease

BMC Gastroenterology

Study Protocol

Esther Assor¹  Farid H. Mahmud¹  Natasha Hamilton²  Tammy Cooper³  Marilyn Fry⁴  Margaret A. Marcon⁵ 

[1] Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;Division of Endocrinology Paediatrics, London Health Sciences Centre, London, ON, Canada;Division of Endocrinology and Metabolism, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada;Division of Endocrinology, Markham Stouffville Hospital, Toronto, ON, Canada;Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;

关键词: Celiac Disease;    Glycemic Index;    Food Record;    Celiac Disease Patient;    Glycemic Load;   

DOI  :  10.1186/s12876-015-0413-0

 received in 2015-11-06, accepted in 2015-12-14,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundCeliac Disease occurs at a 5–10 fold greater prevalence in patients with type-1 diabetes (T1D), despite this increased risk, there is limited objective evidence regarding the impact of a Gluten-Free Diet (GFD) in the large proportion of asymptomatic (30–70 %) patients with both autoimmune diseases. Given the requirements and intricacies inherent to each condition, we describe the rationale and design a dietary curriculum specifically addressing the educational requirements for children and adults with CD and diabetes as part of the CD-DIET Study.Methods and designThe CD-DIET Study (Celiac Disease and Diabetes - Dietary Intervention and Evaluation Trial) is a multicenter randomized controlled trial aimed at evaluating the safety and efficacy of a GFD in patients with asymptomatic celiac disease and T1D on key diabetes and patient-centered outcomes.DiscussionKey dietary components of the trial include a description and evaluation of food consumption patterns including glycemic index and glycemic load, novel assessments of gluten quantification, and objective and subjective measures of GFD adherence. This dietary curriculum will establish rigorous guidelines to assess adherence and facilitate evaluation of a GFD on metabolic control, bone health and patient quality of life in patients with CD and diabetes.Trial registration NumberNCT01566110. Date of Registration: March, 2012.

【 授权许可】

CC BY   
© Assor et al. 2015