Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders

BMC Musculoskeletal Disorders

Research Article

Albert G. Crenshaw¹  David M. Hallman¹  Fredrik Hellström¹  Svend Erik Mathiassen¹  Martin Björklund²  Judith E. Gold³  Mary F. Barbe⁴  Sayed Ali⁵ 

[1] Centre for Musculoskeletal Research, Department of Occupational and Public Health Sciences, University of Gävle, Gävle, Sweden;Centre for Musculoskeletal Research, Department of Occupational and Public Health Sciences, University of Gävle, Gävle, Sweden;Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden;Centre for Musculoskeletal Research, Department of Occupational and Public Health Sciences, University of Gävle, Gävle, Sweden;Gold Standard Research Consulting, 830 Montgomery Ave, Bryn Mawr, PA, USA;Department of Anatomy and Cell Biology, Temple University Medical School, Philadelphia, PA, USA;Department of Radiology, Temple University Medical School, Philadelphia, PA, USA;

关键词: MRI;    MSD;    Near-infrared spectroscopy;    Pain;    Ultrasound;   

DOI  :  10.1186/s12891-017-1694-y

 received in 2017-01-12, accepted in 2017-07-24,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThis study systematically summarizes quantitative imaging biomarker research in non-traumatic neck and shoulder musculoskeletal disorders (MSDs). There were two research questions: 1) Are there quantitative imaging biomarkers associated with the presence of neck and shoulder MSDs?, 2) Are there quantitative imaging biomarkers associated with the severity of neck and shoulder MSDs?MethodsPubMed and SCOPUS were used for the literature search. One hundred and twenty-five studies met primary inclusion criteria. Data were extracted from 49 sufficient quality studies.ResultsMost of the 125 studies were cross-sectional and utilized convenience samples of patients as both cases and controls. Only half controlled for potential confounders via exclusion or in the analysis. Approximately one-third reported response rates. In sufficient quality articles, 82% demonstrated at least one statistically significant association between the MSD(s) and biomarker(s) studied. The literature synthesis suggested that neck muscle size may be decreased in neck pain, and trapezius myalgia and neck/shoulder pain may be associated with reduced vascularity in the trapezius and reduced trapezius oxygen saturation at rest and in response to upper extremity tasks. Reduced vascularity in the supraspinatus tendon may also be a feature in rotator cuff tears. Five of eight studies showed an association between a quantitative imaging marker and MSD severity.ConclusionsAlthough research on quantitative imaging biomarkers is still in a nascent stage, some MSD biomarkers were identified. There are limitations in the articles examined, including possible selection bias and inattention to potentially confounding factors. Recommendations for future studies are provided.

【 授权许可】

CC BY   
© The Author(s). 2017