Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

BMC Cancer

Research Article

Katsuhiko Yanaga¹  Michiaki Watanabe¹  Tsutomu Sugiura²  Seryna Tamez²  Akira Shimojima²  Chihiro Norizoe²  Yusuke Tsutsumi²  Daisuke Takahashi²  Hidetoshi Mezawa³  Mitsuyoshi Urashima³ 

[1] Department of Surgery, Jikei University School of Medicine, Nishi-shimbashi, Minato-ku, Tokyo, Japan;Division of Molecular Epidemiology, Jikei University School of Medicine, Nishi-shimbashi, Minato-ku, Tokyo, Japan;Division of Molecular Epidemiology, Jikei University School of Medicine, Nishi-shimbashi, Minato-ku, Tokyo, Japan;Department of Paediatrics, Jikei University School of Medicine, Nishi-shimbashi, Minato-ku, Tokyo, Japan;

关键词: Colorectal Cancer;    Residual Tumor;    25OHD Level;    Serum 25OHD Level;    Colorectal Cancer Mortality;   

DOI  :  10.1186/1471-2407-10-347

 received in 2009-09-17, accepted in 2010-07-02,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundRecently, serum 25-hydroxyvitamin D (25OHD) levels were shown to be associated with the survival of patients with colorectal cancer. However, 25OHD levels were measured a median of 6 years before diagnosis or were predicted levels. In this study, we directly measured serum 25OHD levels at surgery and examined the association with survival among patients with colorectal cancer.MethodsWe started a prospective cohort study to find prognostic factors in patients with colorectal cancer from 2003 to 2008 and stored serum samples and clinical data. As part of a post-hoc analysis, serum 25OHD levels were measured by radioimmunoassay. Association between overall survival and serum 25OHD levels were computed using the Cox proportional hazard model adjusted for month of serum sampling as well as age at diagnosis, gender, cancer stage, residual tumor after surgery, time period of surgery, location of tumor, adjuvant chemotherapy and number of lymph nodes with metastasis at surgery. Unadjusted and adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) were determined.ResultsSerum 25OHD levels were measured in 257 patients. Only 3% had sufficient levels (30 ng/ml and greater). Based on month of blood sampling, an annual oscillation of 25OHD levels was seen, with levels being lower in spring and higher in late summer. Higher 25OHD levels were associated with better overall survival under multi-variate analysis (HR, 0.91: 95% CI, 0.84 to 0.99, P = 0.027).ConclusionsThese results suggest that higher 25OHD levels at surgery may be associated with a better survival rate of patients with colorectal cancer.

【 授权许可】

Unknown   
© Mezawa et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.