Long term follow up and retrospective study on 533 gastric cancer cases

BMC Surgery

Research Article

Hao-Liang Zhao¹  Jian-Ding Li²  Wen-Qin Hu³  Shu-Guang Yan³  Chun-Wei Peng⁴  Lin-Wei Wang⁴  Wei-Juan Zeng⁴  Gui-Fang Yang⁴  Yan Li⁴ 

[1] Department of General Surgery, Shanxi University Hospital, No 99, Longcheng Street, 046000, Taiyuan CityShangxi Province, China;Department of Medical Imaging, The First Affiliated Hospital of Shanxi Medical University, No 85, South Jiefang Road, 030001, Taiyuan City, Shangxi Province, China;Department of Surgery, Heji Hospital Affiliated to Changzhi Medical College, 046000, Changzhi, China;Departments of Oncology & Pathology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, 430071, Wuhan, China;

关键词: Gastric cancer;    GC-specific overall survival;    Prognosis;    Multivariate analysis;    Clinical pathological factors;   

DOI  :  10.1186/1471-2482-14-29

 received in 2012-12-02, accepted in 2014-05-08,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundGastric cancer (GC) is the third leading cause of cancer death in China and the outcome of GC patients is poor. The aim of the research is to study the prognostic factors of gastric cancer patients who had curative intent or palliative resection, completed clinical database and follow-up.MethodsThis retrospective study analyzed 533 GC patients from three tertiary referral teaching hospitals from January 2004 to December 2010 who had curative intent or palliative resection, complete clinical database and follow-up information. The GC-specific overall survival (OS) status was determined by the Kaplan-Meier method, and univariate analysis was conducted to identify possible factors for survival. Multivariate analysis using the Cox proportional hazard model and a forward regression procedure was conducted to define independent prognostic factors.ResultsBy the last follow-up, the median follow-up time of 533 GC patients was 38.6 mo (range 6.9-100.9 mo), and the median GC-specific OS was 25.3 mo (95% CI: 23.1-27.4 mo). The estimated 1-, 2-, 3- and 5-year GC-specific OS rates were 78.4%, 61.4%, 53.3% and 48.4%, respectively. Univariate analysis identified the following prognostic factors: hospital, age, gender, cancer site, surgery type, resection type, other organ resection, HIPEC, LN status, tumor invasion, distant metastases, TNM stage, postoperative SAE, systemic chemotherapy and IP chemotherapy. In multivariate analysis, seven factors were identified as independent prognostic factors for long term survival, including resection type, HIPEC, LN status, tumor invasion, distant metastases, postoperative SAE and systemic chemotherapy.ConclusionsResection type, HIPEC, postoperative SAE and systemic chemotherapy are four independent prognostic factors that could be intervened for GC patients for improving survival.

【 授权许可】

Unknown   
© Zeng et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.