Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC)

BMC Cancer

Research Article

Yunpeng Yang¹  Ting Zhou¹  Yaxiong Zhang¹  Yuanyuan Zhao¹  Zhonghan Zhang¹  Xue Hou¹  Li Zhang¹  Yan Huang¹  Jianhua Zhan¹  Wenfeng Fang¹  Xiaobo He² 

[1] Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, 510060, Guangzhou, People’s Republic of China;State Key Laboratory of Oncology in South China, 510060, Guangzhou, People’s Republic of China;Collaborative innovation Center for Cancer Medicine, 510060, Guangzhou, People’s Republic of China;Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-Sen University, 519000, Zhuhai, People’s Republic of China;

关键词: Small-cell lung cancer;    Low-density lipoprotein;    Low-density lipoprotein receptor;    Prognosis;   

DOI  :  10.1186/s12885-017-3239-z

 received in 2016-09-09, accepted in 2017-03-28,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPatients with small-cell lung cancer (SCLC) patients demonstrate varied survival outcomes. Previous studies have reported that lipoproteins are associated with prognosis in various cancers; however, the role of low-density lipoprotein (LDL) and low-density lipoprotein- cholesterol (LDLR) in patients with SCLC has not been studied.MethodsIn this study, the impact of LDL and LDLR on the prognosis of SCLC patients was evaluated. A total of 601 patients with SCLC were retrospectively evaluated, in which 198 patients had adequate tissues for immunohistochemistry, and serum LDL and LDLR expression levels at baseline were tested. X-tile tool, and univariate and multivariate Cox analysis were used to assess the association between LDL, LDLR and overall survival (OS).ResultsUnivariate analysis demonstrated that a lower LDL level was significantly associated with superior OS (P = 0.037). Similarly, LDLR also significantly predicted OS (P = 0.003). Multivariate Cox analyses confirmed that lower LDL and LDLR expression was independent prognostic factors associated with longer OS (P = 0.019 and P = 0.027, respectively).ConclusionsThis study showed that both LDL and LDLR are prognostic indexes for survival in patients with SCLC. Patients with high LDL or LDLR expression level may benefit from treatment that modulates lipoprotein combined with platinum-based chemotherapy.

【 授权许可】

CC BY   
© The Author(s). 2017