An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo

BMC Genomics

Research Article

Joern Soehle¹  Anja Knott¹  Marc Winnefeld¹  Stefan Gallinat¹  Lara Terstegen¹  Horst Wenck¹  Janosch Hildebrand²  Nicola Zamboni³  Andreas Kuehne⁴ 

[1] Beiersdorf AG, R&D, Skin Research Center, Unnastrasse 48, 20253, Hamburg, Germany;Coburg University of Applied Sciences and Arts, Friedrich-Streib-Straße 2, 96450, Coburg, Germany;Institute of Molecular Systems Biology, ETH Zurich, Auguste-Piccard-Hof 1, 8093, Zürich, Switzerland;Institute of Molecular Systems Biology, ETH Zurich, Auguste-Piccard-Hof 1, 8093, Zürich, Switzerland;PhD Program Systems Biology, Life Science Zurich Graduate School, Zurich, Switzerland;

关键词: Skin;    Aging;    Metabolism;    Metabolomics;    Transcriptomics;    Systems biology;   

DOI  :  10.1186/s12864-017-3547-3

 received in 2016-09-07, accepted in 2017-02-02,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAging human skin undergoes significant morphological and functional changes such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier function. Besides known age-related alterations like DNA-methylation changes, metabolic adaptations have been recently linked to impaired skin function in elder humans. Understanding of these metabolic adaptations in aged skin is of special interest to devise topical treatments that potentially reverse or alleviate age-dependent skin deterioration and the occurrence of skin disorders.ResultsWe investigated the global metabolic adaptions in human skin during aging with a combined transcriptomic and metabolomic approach applied to epidermal tissue samples of young and old human volunteers. Our analysis confirmed known age-dependent metabolic alterations, e.g. reduction of coenzyme Q10 levels, and also revealed novel age effects that are seemingly important for skin maintenance. Integration of donor-matched transcriptome and metabolome data highlighted transcriptionally-driven alterations of metabolism during aging such as altered activity in upper glycolysis and glycerolipid biosynthesis or decreased protein and polyamine biosynthesis. Together, we identified several age-dependent metabolic alterations that might affect cellular signaling, epidermal barrier function, and skin structure and morphology.ConclusionsOur study provides a global resource on the metabolic adaptations and its transcriptional regulation during aging of human skin. Thus, it represents a first step towards an understanding of the impact of metabolism on impaired skin function in aged humans and therefore will potentially lead to improved treatments of age related skin disorders.

【 授权许可】

CC BY   
© The Author(s). 2017

【 图 表 】

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