Up-to-date on mortality in COPD - report from the OLIN COPD study

BMC Pulmonary Medicine

Research Article

Anne Lindberg¹  Bo Lundbäck²  Eva Rönmark³  Lars-Gunnar Larsson⁴  Hana Muellerova⁵ 

[1] Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, SE-901 85, Umeå, Sweden;The OLIN studies and Division of Respiratory Medicine & Allergy, Sunderby Hospital, SE-971 80, Luleå, Sweden;Division of Respiratory Medicine & Allergy, Sunderby Hospital, SE-971 80, Luleå, Sweden;The OLIN studies and Division of Respiratory Medicine & Allergy, Sunderby Hospital, SE-971 80, Luleå, Sweden;Department of Internal Medicine/Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, SE-405 30, Gothenburg, Sweden;The OLIN studies and Division of Respiratory Medicine & Allergy, Sunderby Hospital, SE-971 80, Luleå, Sweden;Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, Umeå University, SE-901 85, Umeå, Sweden;The OLIN studies and Division of Respiratory Medicine & Allergy, Sunderby Hospital, SE-971 80, Luleå, Sweden;Division of Respiratory Medicine & Allergy, Sunderby Hospital, SE-971 80, Luleå, Sweden;WorldWide Epidemiology, GlaxoSmithKline R&D, Stockley Park, UB11 1BT, Uxbridge, Middlesex, UK;

关键词: Chronic Obstructive Pulmonary Disease;    Lung Function;    Idiopathic Pulmonary Fibrosis;    Significant Risk Factor;    Severe Chronic Obstructive Pulmonary Disease;   

DOI  :  10.1186/1471-2466-12-1

 received in 2011-04-03, accepted in 2012-01-09,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe poor recognition and related underdiagnosis of COPD contributes to an underestimation of mortality in subjects with COPD. Data derived from population studies can advance our understanding of the true burden of COPD. The objective of this report was to evaluate the impact of COPD on mortality and its predictors in a cohort of subjects with and without COPD recruited during the twenty first century.MethodsAll subjects with COPD (n = 993) defined according to the GOLD spirometric criteria, FEV1/FVC < 0.70, and gender- and age-matched subjects without airway obstruction, non-COPD (n = 993), were identified in a clinical follow-up survey of the Obstructive Lung Disease in Northern Sweden (OLIN) Studies cohorts in 2002-2004. Mortality was observed until the end of year 2007. Baseline data from examination at recruitment were used in the risk factor analyses; age, smoking status, lung function (FEV1 % predicted) and reported heart disease.ResultsThe mortality was significantly higher among subjects with COPD, 10.9%, compared to subjects without COPD, 5.8% (p < 0.001). Mortality was associated with higher age, being a current smoker, male gender, and COPD. Replacing COPD with FEV1 % predicted in the multivariate model resulted in the decreasing level of FEV1 being a significant risk factor for death, while heart disease was not a significant risk factor for death in any of the models.ConclusionsIn this cohort COPD and decreased FEV1 were significant risk factors for death when adjusted for age, gender, smoking habits and reported heart disease.

【 授权许可】

CC BY   
© Lindberg et al; licensee BioMed Central Ltd. 2012