The impact of omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular events and complications in peripheral arterial disease: a systematic review and meta-analysis

BMC Cardiovascular Disorders

Research Article

Ryan Zarychanski¹  Azadeh Yeganeh²  Jennifer E Enns²  Peter Zahradka³  Carla G Taylor³  Ahmed M Abou-Setta⁴  Carol Friesen⁵ 

[1] Department of Internal Medicine, University of Manitoba, Health Sciences Centre, 820 Sherbrook St, R3T 2N2, Winnipeg, Canada;George & Fay Yee Centre for Healthcare Innovation/Winnipeg Regional Health Authority, Health Sciences Centre, University of Manitoba, 820 Sherbrook St, R3T 2N2, Winnipeg, Canada;Department of Physiology, University of Manitoba, Winnipeg, Canada;Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Research Centre, R2019-351R2H 2A6, Taché Ave, Winnipeg, Canada;Department of Physiology, University of Manitoba, Winnipeg, Canada;Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Research Centre, R2019-351R2H 2A6, Taché Ave, Winnipeg, Canada;Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada;George & Fay Yee Centre for Healthcare Innovation/Winnipeg Regional Health Authority, Health Sciences Centre, University of Manitoba, 820 Sherbrook St, R3T 2N2, Winnipeg, Canada;Neil John Maclean Health Sciences Library, University of Manitoba Libraries, 770 Bannatyne Ave, R3E 0W3, Winnipeg, Canada;

关键词: Omega-3 polyunsaturated fatty acid;    Peripheral arterial disease;    Intermittent claudication;   

DOI  :  10.1186/1471-2261-14-70

 received in 2014-03-17, accepted in 2014-05-28,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIndividuals with peripheral arterial disease are at higher risk for cardiovascular events than the general population. While supplementation with omega-3 polyunsaturated fatty acids (PUFA) has been shown to improve vascular function, it remains unclear if supplementation decreases serious clinical outcomes. We conducted a systematic review and meta-analysis to determine whether omega-3 PUFA supplementation reduces the incidence of cardiovascular events and complications in adults with peripheral arterial disease.MethodsWe searched five electronic databases (MEDLINE, EMBASE, CENTRAL, Scopus and the International Clinical Trials Registry Platform) from inception to 6 December 2013 to identify randomized trials of omega-3 PUFA supplementation (from fish or plant oils) that lasted ≥12 weeks in adults with peripheral arterial disease. No language filters were applied. Data on trial design, population characteristics, and health outcomes were extracted. The primary outcome was major adverse cardiac events; secondary outcomes included myocardial infarction, cardiovascular death, stroke, angina, amputation, revascularization procedures, maximum and pain-free walking distance, adverse effects of the intervention, and quality of life. Trial quality was assessed using the Cochrane Risk of Bias tool.ResultsOf 741 citations reviewed, we included five trials enrolling 396 individuals. All included trials were of unclear or high risk of bias. There was no evidence of a protective association of omega-3 PUFA supplementation against major adverse cardiac events (pooled risk ratio 0.73, 95% CI 0.22 to 2.41, I2 75%, 2 trials, 288 individuals) or other serious clinical outcomes. Adverse events and compliance were poorly reported.ConclusionsOur results showed that insufficient evidence exists to suggest a beneficial effect of omega-3 PUFA supplementation in adults with peripheral arterial disease with regard to cardiovascular events and other serious clinical outcomes.

【 授权许可】

Unknown   
© Enns et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.