Pulse wave velocity and carotid atherosclerosis in White and Latino patients with hypertension

BMC Cardiovascular Disorders

Research Article

Elhum Karimkhani¹  Frederick A Masoudi²  Mori J Krantz²  Carlin S Long²  Raymond O Estacio²  Edward P Havranek²  Patrick Hosokawa³  Miriam Dickinson³ 

[1] Cardiology Division, Denver Health Medical Center, Denver, USA;Cardiology Division, Denver Health Medical Center, Denver, USA;Department of Medicine, University of Colorado School of Medicine, Aurora, USA;Department of Family Medicine, University of Colorado School of Medicine, Aurora, USA;

关键词: Pulse wave velocity;    hypertension;    atherosclerosis;    carotid intima media thickness;    Latino;    inflammatory markers;    augmentation index;    central aortic pressure;    C-reactive protein;   

DOI  :  10.1186/1471-2261-11-15

 received in 2010-11-07, accepted in 2011-04-11,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundPreventive cardiology has expanded beyond coronary heart disease towards prevention of a broader spectrum of cardiovascular diseases. Ethnic minorities are at proportionately greater risk for developing extracoronary vascular disease including heart failure and cerebrovascular disease.MethodsWe performed a cross sectional study of Latino and White hypertension patients in a safety-net healthcare system. Framingham risk factors, markers of inflammation (hsCRP, LPpLA2), arterial stiffness (Pulse wave velocity, augmentation index, and central aortic pressure), and endothelial function (brachial artery flow-mediated dilatation) were measured. Univariate and multivariable associations between these parameters and an index of extracoronary atherosclerosis (carotid intima media thickness) was performed.ResultsAmong 177 subjects, mean age was 62 years, 67% were female, and 67% were Latino. In univariate analysis, markers associated with carotid intima media thickness (IMT) at p < 0.25 included pulse wave velocity (PWV), augmentation index (AIx), central aortic pressure (cAP), and LpPLA2 activity rank. However, AIx, cAP, and LpPLA2 activity were not significantly associated with carotid IMT after adjusting for Framingham risk factors (all p > .10). Only PWV retained a significant association with carotid IMT independent of the Framingham general risk profile parameters (p = .016). No statistically significant interactions between Framingham and other independent variables with ethnicity (all p > .05) were observed.ConclusionIn this safety net cohort, PWV is a potentially useful adjunctive atherosclerotic risk marker independent of traditional risk factors and irrespective of ethnicity.

【 授权许可】

CC BY   
© Krantz et al; licensee BioMed Central Ltd. 2011