Cervical cytology and human papillomavirus among asymptomatic healthy volunteers in Vientiane, Lao PDR

BMC Cancer

Research Article

Kentarou Ohtake¹  Reika Takamatsu²  Naoki Yoshimi²  Katsu Nakasone³  Phouthasone Mounthisone⁴  Viengvansay Nabandith⁵  Vatsana Pholsena⁵ 

[1] Clinical Laboratory, Medical Examination Center of Chubu Medical Association, 1-584 Miyagi, Chatan-cho, Nakagami-gun, 904-0113, Okinawa, Japan;Department of Pathology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Nakagami-gun, 903-0215, Okinawa, Japan;Department of Pathology, Ryukyu University Hospital, 207 Uehara, Nishihara-cho, Nakagami-gun, 903-0215, Okinawa, Japan;Mittaphab Hospital, Phonsavang Village, P.O.Box 6035, Chanthabouly District, Vientiane, Lao PDR;Setthathirath Hospital, Donekoi Village, P.O.Box 527, Sisatthanak District, Vientiane, Lao PDR;

关键词: Human papillomavirus (HPV);    Cytology;    HPV testing;    Vientiane;   

DOI  :  10.1186/s12885-017-3900-6

 received in 2016-11-23, accepted in 2017-12-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCervical cancer is the most common cancer in women living in Vientiane, Lao People’s Democratic Republic (PDR). This study examines cervical cytology using a liquid-based cytology (LBC) method and reports the presence of high-risk (HR) human papillomavirus (HPV).MethodsWe collected cervical samples from 1475 asymptomatic and healthy volunteers from six hospitals in Lao PDR. A total of 1422 volunteers (mean age 39.1 ± 6.4 years, range 30-54 years) were included in the final analysis. We performed HPV typing using the polymerase chain reaction technique to detect HR-HPV samples with abnormal cytology.ResultsThe overall rates of abnormal cytology and HR-HPV–positive in the samples were 9.3% (132/1422) and 47.7% (63/132), respectively. The samples with abnormal cytology included 13 high-grade squamous intraepithelial lesions and one squamous cell carcinoma case. The results showed that the most common type of HPV was HPV16 (20.5%) followed by HPV58 (9.1%).ConclusionsHealthy women in Vientiane, the capital of Lao PDR, have high rates of abnormal cervical cytology and are likely to be HR-HPV-positive. A system for detection and prevention of cervical cancer in these women should be developed in the near future.

【 授权许可】

CC BY   
© The Author(s). 2017