Acute rhabdomyolysis and delayed pericardial effusion in an Italian patient with Ebola virus disease: a case report

BMC Infectious Diseases

Case Report

Timothy M. Uyeki¹  Antonio Brucato²  Nicola Petrosillo³  Emanuele Nicastri³  Giuseppe Ippolito³  Gianluigi Biava³ 

[1] Centers for Disease Control and Prevention, Atlanta, GA, USA;Internal Medicine Ospedale Papa Giovanni XXIII, Bergamo, Italy;National Institute for Infectious Diseases – INMI - Lazzaro Spallanzani IRCCS, Via Portuense 292, 00149, Rome, Italy;

关键词: Ebola Virus Disease;    Rhabdomyolysis;    Pericardial effusion;   

DOI  :  10.1186/s12879-017-2689-x

 received in 2017-01-12, accepted in 2017-08-16,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDuring the 2013–2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA.Case presentationIn May 2015, a 37-year old male nurse contracted Ebola virus disease in Sierra Leone. After Ebola virus detection in plasma, he was medically-evacuated to Italy. At admission, rhabdomyolysis was clinically and laboratory-diagnosed and was treated with aggressive hydration, oral favipiravir and intravenous investigational monoclonal antibodies against Ebola virus. The recovery clinical phase was complicated by a febrile thrombocytopenic syndrome with pericardial effusion treated with corticosteroids for 10 days and indomethacin for 2 months. No evidence of recurrence is reported.ConclusionsA febrile thrombocytopenic syndrome with pericardial effusion during the recovery phase of EVD appears to be uncommon. Clinical improvement with corticosteroid treatment suggests that an immune-mediated mechanism contributed to the pericardial effusion.

【 授权许可】

CC BY   
© The Author(s). 2017