Obesity is an independent risk factor for pre-transplant portal vein thrombosis in liver recipients

BMC Gastroenterology

Research Article

Alvaro García-Sesma¹  Carlos Jimenez¹  Enrique Moreno¹  Silvia Grande²  Joaquín Martínez-López²  Carmen Ribera²  Rosa Ayala³  Rosalía Bustelos⁴ 

[1] General Surgery Alimentary Tract and Abdominal Organ Transplantation Department, 12 De Octubre University Hospital, Madrid, Spain;Hematology Department, 12 De Octubre University Hospital, Avenida Córdoba s/n, 28041, Madrid, Spain;Hematology Department, 12 De Octubre University Hospital, Avenida Córdoba s/n, 28041, Madrid, Spain;Complutense De Madrid University, Madrid, Spain;Hematology Department, Sureste Hospital (Arganda), Madrid, Spain;

关键词: Thrombophilia;    Portal vein thrombosis;    Liver transplant recipient;   

DOI  :  10.1186/1471-230X-12-114

 received in 2011-11-06, accepted in 2012-07-26,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPortal vein thrombosis is a frequent complication in end-stage cirrhosis with a considerable peri-operative risk for liver transplant candidates. We aimed to characterize the pre-transplant portal vein thrombosis in a cohort of liver transplant recipients, and to identify independent risk factors for this complication.Methods380 consecutive primary orthotopic liver transplants were performed in the Digestive Surgery Department of “12 de Octubre” Hospital (Madrid, Spain), between January 2001 and December 2006. The main risk factors considered were smoking, obesity, metabolic disorders, previous immobility, surgery or trauma, nephrotic syndrome, associated tumor, inflammatory disease, neoplasm myeloprolipherative. Furthermore we have reported genetic thrombophilia results for 271 recipients.ResultsSixty-two (16.3%) patients developed pre-transplant portal vein thrombosis and its presence had no impact in the overall survival of liver recipients. Obesity was the only independent risk factor for pre-transplant portal vein thrombosis.ConclusionWe recommend close control of cardiovascular factors in patients with liver cirrhosis in order to avoid associated thrombosis.

【 授权许可】

CC BY   
© Ayala et al.; licensee BioMed Central Ltd. 2012