Younger age as a prognostic indicator in breast cancer: A cohort study

BMC Cancer

Research Article

Cara Dooley¹  Jennifer ME Boggs²  Elrasheid AH Kheirelseid²  Karl J Sweeney²  Catherine Curran²  Ronan W Glynn²  Michael J Kerin² 

[1] Biostatistics Unit, National University of Ireland, Galway, Ireland;Department of Surgery, National University of Ireland, Galway, Ireland;

关键词: Breast Cancer;    Overall Survival;    Invasive Lobular Carcinoma;    Ovarian Ablation;    International Breast Cancer Study Group;   

DOI  :  10.1186/1471-2407-11-383

 received in 2010-09-22, accepted in 2011-08-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe debate continues as to whether younger women who present with breast cancer have a more aggressive form of disease and a worse prognosis. The objectives of this study were to determine the incidence of breast cancer in women under 40 years old and to analyse the clinicopathological characteristics and outcome compared to an older patient cohort.MethodsData was acquired from a review of charts and the prospectively reviewed GUH Department of Surgery database. Included in the study were 276 women diagnosed with breast cancer under the age of forty and 2869 women over forty. For survival analysis each women less than 40 was matched with two women over forty for both disease stage and grade.ResultsThe proportion of women diagnosed with breast cancer under the age of forty in our cohort was 8.8%. In comparison to their older counterparts, those under forty had a higher tumour grade (p = 0.044) and stage (p = 0.046), a lower incidence of lobular tumours (p < 0.001), higher estrogen receptor negativity (p < 0.001) and higher HER2 over-expression (p = 0.002); there was no statistical difference as regards tumour size (p = 0.477). There was no significant difference in overall survival (OS) for both groups; and factors like tumour size (p = 0.026), invasion (p = 0.026) and histological type (p = 0.027), PR (p = 0.031) and HER2 (p = 0.002) status and treatment received were independent predictors of OSConclusionBreast cancer in younger women has distinct histopathological characteristics; however, this does not result in a reduced survival in this population.

【 授权许可】

Unknown   
© H Kheirelseid et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.