The modified Gingyo-san, a Chinese herbal medicine, has direct antibacterial effects against respiratory pathogens

BMC Complementary and Alternative Medicine

Research Article

Hidemasa Nakaminami¹  Takeaki Wajima¹  Kaho Kobayashi¹  Norihisa Noguchi¹  Hideaki Ikoshi²  Tetsuya Yamada² 

[1] Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, 192-0392, Hachiouji, Tokyo, Japan;Department of Traditional Chinese Medicine, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan;

关键词: Modified Gingyo-san;    Respiratory pathogen;    Chinese herbal medicine;   

DOI  :  10.1186/s12906-016-1431-3

 received in 2016-09-21, accepted in 2016-10-27,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundModified Gingyo-san (MGS) is empirically used to treat various respiratory infections. MGS has been reported to have antiinflammatory and antiviral activities; however, it is not known if it has an antibacterial activity. Therefore, in this study, we aimed to investigate the antimicrobial activity of MGS against respiratory pathogens.MethodsMGS, which is sold as an over-the-counter drug in Japan, was used for the study. Antimicrobial activity was evaluated using the disk diffusion method. Growth inhibitory activity was evaluated by measuring colony-forming units of the pathogens in the presence of MGS.ResultsMGS inhibited the growth of Bacillus subtilis, Streptococcus pneumoniae, and Streptococcus pyogenes, which are gram-positive bacteria. Although the growth of most gram-negative bacteria was not inhibited by MGS, interestingly, the growth of Haemophilus influenzae was inhibited. MGS did not show any activity against Candida albicans or bacteriophage φX174.ConclusionsIn addition to the antiinflammatory and antiviral activities of MGS, which have already been reported, the data obtained from this study indicates that MGS has an antibacterial activity.

【 授权许可】

CC BY   
© The Author(s). 2016