Childhood asthma and physical activity: a systematic review with meta-analysis and Graphic Appraisal Tool for Epidemiology assessment

BMC Pediatrics

Research Article

Thomas A. E. Platts-Mills¹  Lene Lochte²  Poul Erik Petersen²  Kim G. Nielsen³ 

[1] Department of Medicine, Division of Allergy and Clinical Immunology, University of Virginia, 22908, Charlottesville, VA, USA;Department of Odontology, University of Copenhagen, 1014, Copenhagen, Denmark;Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark;

关键词: Systematic review;    Pediatric;    Asthmatic disease;    Exercise;   

DOI  :  10.1186/s12887-016-0571-4

 received in 2015-09-18, accepted in 2016-03-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundChildhood asthma is a global problem affecting the respiratory health of children. Physical activity (PA) plays a role in the relationship between asthma and respiratory health. We hypothesized that a low level of PA would be associated with asthma in children and adolescents. The objectives of our study were to (1) summarize the evidence available on associations between PA and asthma prevalence in children and adolescents and (2) assess the role of PA in new-onset or incident asthma among children and adolescents.MethodsWe searched Medline, the Cochrane Library, and Embase and extracted data from original articles that met the inclusion criteria. Summary odds ratios (ORs) and confidence intervals (CIs) were used to express the results of the meta-analysis (forest plot). We explored heterogeneity using funnel plots and the Graphic Appraisal Tool for Epidemiology (GATE).ResultsWe retrieved 1,571 titles and selected 11 articles describing three cohort and eight cross-sectional studies for inclusion. A meta-analysis of the cohort studies revealed a risk of new-onset asthma in children with low PA (OR [95 % CI] 1.32 [0.95; 1.84] [random effects] and 1.35 [1.13; 1.62] [fixed effects]). Three cross-sectional studies identified significant positive associations between childhood asthma or asthma symptoms and low PA.ConclusionsChildren and adolescents with low PA levels had an increased risk of new-onset asthma, and some had a higher risk of current asthma/or wheezing; however, there was some heterogeneity among the studies. This review reveals a critical need for future longitudinal assessments of low PA, its mechanisms, and its implications for incident asthma in children. The systematic review was prospectively registered at PROSPERO (registration number: CRD42014013761; available at: http://www.crd.york.ac.uk/PROSPERO [accessed: 24 March 2016]).

【 授权许可】

CC BY   
© Lochte et al. 2016