Visual outcome of mega-dose intravenous corticosteroid treatment in non-arteritic anterior ischemic optic neuropathy – retrospective analysis

BMC Ophthalmology

Research Article

Angela Chetrit¹  Iris Ben-Bassat²  Yael Wasserzug²  Ruth Huna-Baron²  Michael Kinori³ 

[1] Gertner Institute for Research and Epidemiology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;Neuro-Ophthalmology unit, The Goldschleger Eye Institute, Sheba Medical Center, Tel- Hashomer, Israel affiliated to the Sackler school of medicine, Tel Aviv university, Tel Aviv, Israel;Neuro-Ophthalmology unit, The Goldschleger Eye Institute, Sheba Medical Center, Tel- Hashomer, Israel affiliated to the Sackler school of medicine, Tel Aviv university, Tel Aviv, Israel;The Pinchas Borenstein Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;

关键词: Anterior ischemic optic neuropathy;    Corticosteroids;    Visual acuity;    Visual field;    Mean deviation;   

DOI  :  10.1186/1471-2415-14-62

 received in 2014-02-21, accepted in 2014-04-28,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundTo date, non arteritic anterior ischemic optic neuropathy (NAION) is still incurable. We wish to evaluate the effect of intravenous (IV) corticosteroids on the visual outcome of NAION patients.MethodsVisual parameters were retrospectively compared between NAION patients treated with IV corticosteroids and untreated NAION patients (control). Visual acuity (VA) and Humphrey automated static perimetry visual field (VF) defects of the affected eye were compared between groups at baseline, 1, 3, 6 months, and end of follow-up visits. The VF analysis consisted of number of quadrant involvements and mean deviation (MD).ResultsEach group comprised 23 patients (24 eyes). Mean initial VA was similar in the control and treatment groups (p = 0.8). VA at end of follow-up did not improve in either groups (p = 0.8 treated group, p = 0.1 control group). No improvement and no difference in VF defects were found by either quadrant analysis (p = 0.1 treated group, p = 0.5 control group) or MD analysis (p = 0.2, treated group, p = 0.9 control group). VA and VF parameters tended to be worse in the treated group, although without statistical significance.ConclusionsOur results suggest that IV corticosteroids may not improve the visual outcome of NAION patients. Since intravenous corticosteroids could potentially cause serious adverse effects, this treatment for NAION is questionable.

【 授权许可】

CC BY   
© Kinori et al.; licensee BioMed Central Ltd. 2014