Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

BMC Genomics

Research Article

Oscar P. Kuipers¹  Xin Zhao² 

[1] Department of Molecular Genetics, University of Groningen, Nijenborgh 7, 9747AG, Groningen, The Netherlands;Department of Molecular Genetics, University of Groningen, Nijenborgh 7, 9747AG, Groningen, The Netherlands;School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, People’s Republic of China;

关键词: Antimicrobials;    Bacillales;    Bacillus;    Genome-mining;    Lanthipeptides;    Sactipeptides;    Thiopeptides;    NRPs;    PKs;   

DOI  :  10.1186/s12864-016-3224-y

 received in 2016-07-02, accepted in 2016-10-27,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundGram-positive bacteria of the Bacillales are important producers of antimicrobial compounds that might be utilized for medical, food or agricultural applications. Thanks to the wide availability of whole genome sequence data and the development of specific genome mining tools, novel antimicrobial compounds, either ribosomally- or non-ribosomally produced, of various Bacillales species can be predicted and classified. Here, we provide a classification scheme of known and putative antimicrobial compounds in the specific context of Bacillales species.ResultsWe identify and describe known and putative bacteriocins, non-ribosomally synthesized peptides (NRPs), polyketides (PKs) and other antimicrobials from 328 whole-genome sequenced strains of 57 species of Bacillales by using web based genome-mining prediction tools. We provide a classification scheme for these bacteriocins, update the findings of NRPs and PKs and investigate their characteristics and suitability for biocontrol by describing per class their genetic organization and structure. Moreover, we highlight the potential of several known and novel antimicrobials from various species of Bacillales.ConclusionsOur extended classification of antimicrobial compounds demonstrates that Bacillales provide a rich source of novel antimicrobials that can now readily be tapped experimentally, since many new gene clusters are identified.

【 授权许可】

CC BY   
© The Author(s). 2016