Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague–Dawley male rats

BMC Complementary and Alternative Medicine

Research Article

G. A. Mavondo¹  C. T. Musabayane¹  B. N. Mkhwananzi¹  M. V. Mabandla¹ 

[1] Discipline of Human Physiology, School of Laboratory Medicine, College of Health Sciences, University of KwaZulu Natal, Private Bag X54001, Westville Campus, 4000, Durban, South Africa;

关键词: Asiatic acid;    Chloroquine;    Malaria parasitaemia;    Plasmodium berghei;   

DOI  :  10.1186/s12906-016-1338-z

 received in 2016-04-22, accepted in 2016-09-03,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCurrent malaria treatment is either “anti-parasitic”, “anti-infectivity” or both without addressing the pathophysiological derangement (anti-disease aspect) associated with the disease. Asiatic acid is a natural phytochemical with oxidant, antioxidant and anti-inflammatory properties whose effect on malarial and accompanying pathophysiology are yet to be investigated. Asiatic acid influence in P. berghei-infected Sprague Dawley rats on %parasitaemia and malarial anaemia were investigated.MethodsPlasmodium berghei-infected rats (90–120 g) were orally administered with Asiatic acid (5, 10, 20 mg/kg) and 30 mg/kg chloroquine as a positive control. Changes in %parasitaemia and haematological parameters in Asiatic acid administered rats were monitored in a 21 day study and compared to controls.ResultsAll animals developed stable parasitaemia (15-20 %) by day 7. Asiatic acid doses suppressed parasitaemia, normalised haematological measurements and influenced biophysical characteristics changes. Most positive changes were associated with intragastric administration of 10 mg/kg Asiatic acid dose. Peak %parasitaemia in Asiatic acid administration occurred at days 12 with a shorter time course compared to day 9 for chloroquine (30 mg/kg) treatment with a longer time course.ConclusionsOral Asiatic acid administration influenced %parasitaemia suppression, ameliorated malarial anaemia and increased biophysical properties on infected animals. Asiatic acid may be a replacement alternative for chloroquine treatment with concomitant amelioration of malaria pathophysiology. Due to different action time courses, Asiatic acid and chloroquine may be possible candidates in combination therapy.

【 授权许可】

CC BY   
© The Author(s). 2016