Southeast Asian diversity: first insights into the complex mtDNA structure of Laos

BMC Evolutionary Biology

Research Article

Basil Horst¹  Anita Kloss-Brandstätter²  Martin Bodner³  Bettina Zimmermann³  Alexander Röck⁴  David Horst⁵ 

[1] Department of Dermatology, Columbia University, New York, NY, USA;Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstrasse 41, Innsbruck, Austria;Institute of Legal Medicine, Innsbruck Medical University, Müllerstrasse 44, Innsbruck, Austria;Institute of Mathematics, University of Innsbruck, Technikerstrasse 13, Innsbruck, Austria;Pathologisches Institut, Ludwig-Maximilians-Universität, Munich, Germany;

关键词: Shared Haplotype;    East Asian Population;    Southeast Asian Population;    Control Region Haplotype;    Random Match Probability;   

DOI  :  10.1186/1471-2148-11-49

 received in 2010-08-02, accepted in 2011-02-18,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundVast migrations and subsequent assimilation processes have shaped the genetic composition of Southeast Asia, an area of close contact between several major ethnic groups. To better characterize the genetic variation of this region, we analyzed the entire mtDNA control region of 214 unrelated donors from Laos according to highest forensic quality standards. To detail the phylogeny, we inspected selected SNPs from the mtDNA coding region. For a posteriori data quality control, quasi-median network constructions and autosomal STR typing were performed. In order to describe the mtDNA setup of Laos more thoroughly, the data were subjected to population genetic comparisons with 16 East Asian groups.ResultsThe Laos sample exhibited ample mtDNA diversity, reflecting the huge number of ethnic groups listed. We found several new, so far undescribed mtDNA lineages in this dataset and surrounding populations. The Laos population was characteristic in terms of haplotype composition and genetic structure, however, genetic comparisons with other Southeast Asian populations revealed limited, but significant genetic differentiation. Notable differences in the maternal relationship to the major indigenous Southeast Asian ethnolinguistic groups were detected.ConclusionsIn this study, we portray the great mtDNA variety of Laos for the first time. Our findings will contribute to clarify the migration history of the region. They encourage setting up regional and subpopulation databases, especially for forensic applications. The Laotian sequences will be incorporated into the collaborative EMPOP mtDNA database http://www.empop.org upon publication and will be available as the first mtDNA reference data for this country.

【 授权许可】

Unknown   
© Bodner et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.