The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers

BMC Cancer

Review

Wei Kang¹  Ka Fai To¹  Tingting Huang¹  Jun Yu²  Alfred S. L. Cheng³ 

[1] Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China;Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China;Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China;Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China;Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China;Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China;Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China;Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China;Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China;School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, PR China;

关键词: Gastric cancer;    Gastrointestinal cancers;    SLIT;    ROBO;    Slit-Robo pathway;    Oncogene;    Tumor suppressor;   

DOI  :  10.1186/s12885-015-1984-4

 received in 2015-07-31, accepted in 2015-12-08,  发布年份 2015

来源: Springer

【 摘 要 】

Gastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancer-related deaths. Due to the high frequency of metastasis, it is still one of the most lethal malignancies in which kinds of signaling pathways are involved in. The Roundabout (ROBO) receptors and their secreted SLIT glycoprotein ligands, which were originally identified as important axon guidance molecules, have implication in the regulation of neurons and glia, leukocytes, and endothelial cells migration. Recent researches also put high emphasis on the important roles of the Slit-Robo pathway in tumorigenesis, cancer progression and metastasis. Herein we provide a comprehensive review on the role of these molecules and their associated signaling pathway in gastric and other gastrointestinal cancers. Improved knowledge of the Slit-Robo signaling pathway in gastric carcinoma will be useful for deep understanding the mechanisms of tumor development and identifying ideal targets of anticancer therapy in gastric carcinoma.

【 授权许可】

CC BY   
© Huang et al. 2015