Association between metabolic syndrome and knee osteoarthritis: a cross-sectional study

BMC Musculoskeletal Disorders

Research Article

Hui-zhong Long¹  Kang-hua Li¹  Guang-hua Lei¹  Dong-xing Xie¹  Yu-xuan Qian¹  Yi-lun Wang¹  Hui Li¹  Zi-ying Wu¹  Tuo Yang¹  Chao Zeng¹  Jie Wei² 

[1] Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, 410008, Changsha, Hunan, People’s Republic of China;Health Management Center, Xiangya Hospital, Central South University, 410008, Changsha, Hunan Province, People’s Republic of China;Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 410008, Changsha, Hunan Province, People’s Republic of China;

关键词: Osteoarthritis;    Metabolic syndrome;    Knee;   

DOI  :  10.1186/s12891-017-1890-9

 received in 2017-06-18, accepted in 2017-12-01,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundOsteoarthritis (OA) is the most prevalent chronic joint disease in China. The aim of this study was to examine the association between metabolic syndrome (MetS) and knee OA in a population-based Chinese study.MethodsData included in this analysis is from a cross-sectional study, i.e., the Xiangya Hospital Health Management Center Study. MetS was diagnosed according to the criteria defined by the Chinese Diabetes Society. Radiographic knee OA was defined as changes equivalent to Kellgren-Lawrence (K-L) grade 2 or above at least one side. Associations between MetS and its components with OA were evaluated by conducting multivariable adjusted logistic regression.ResultsA total of 5764 participants were included in the present study. The unadjusted OR (1.27, 95%CI: 1.10–1.47, P = 0.001), age-sex adjusted OR (1.17, 95%CI: 1.01–1.36, P = 0.041) and multivariable adjusted OR (1.17, 95%CI: 1.01–1.36, P = 0.043) all suggested a positive association between MetS and knee OA. Besides, its components (e.g., overweight, hypertension and dyslipidemia) were also associated with the prevalence of radiographic knee OA respectively, after adjusting for some confounding factors. In addition, with the accumulation of MetS components, the prevalence of knee OA increased. Furthermore, MetS as a whole was associated with the prevalence of knee osteophyte (OSP) (OR = 1.72, 95%CI: 1.42–2.09, P < 0.001), but not joint space narrowing (JSN) (OR = 1.06, 95%CI: 0.91–1.23, P = 0.449).ConclusionsThe findings of the present study indicated that there was a positive association between the prevalence of MetS and knee OA. However, MetS as a whole was associated with the higher prevalence of knee OSP, but not JSN, which should shed light on our understanding the association between MetS and OA.

【 授权许可】

CC BY   
© The Author(s). 2017