Levels of S100B are raised in female patients with schizophrenia

BMC Psychiatry

Research Article

Jogin Thakore¹  Kumlesh K Dev²  Kara O’Connell³ 

[1] Department of Psychiatry, School of Medicine, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland;Neuroscience Centre, St. Vincent’s Hospital Fairview, Fairview, Dublin, Ireland;Molecular Neuropharmacology, Department of Physiology, School of Medicine, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland;Molecular Neuropharmacology, Department of Physiology, School of Medicine, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland;Department of Psychiatry, School of Medicine, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland;Neuroscience Centre, St. Vincent’s Hospital Fairview, Fairview, Dublin, Ireland;

关键词: S100B;    Clozapine;    Antipsychotics;    Metabolic syndrome;    Schizophrenia;   

DOI  :  10.1186/1471-244X-13-146

 received in 2013-01-28, accepted in 2013-05-06,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe neurotrophic factor, S100B, is released primarily from astrocytes, with serum and CSF levels of S100B reported as altered in schizophrenia. However, many of these reports are contradictory. Here, serum levels of S100B in schizophrenia and influence of age, gender, medication and illness severity were examined.MethodsSerum S100B levels were measured in patients with schizophrenia treated with clozapine. Lifestyle, metabolic and illness severity parameters were correlated with S100B concentrations.ResultsData showed raised serum levels of S100B in schizophrenia female patients, but not male patients, compared to controls. Correlation analysis demonstrated a positive association between S100B serum concentrations and BMI.ConclusionsThis study supports previous findings that adipocytes may contribute to S100B serum concentrations in females, in addition to astrocytes. This study also supports the hypothesis that metabolic effects of medication, lifestyle choices and the illness itself, may be contributing factors to altered levels of S100B.

【 授权许可】

Unknown   
© O’Connell et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.