Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus × Bos indicus)

BMC Genomics

Research Article

Gustavo Gasparin¹  Simone EF Guimarães²  Maria A Pires³  Márcia Cristina A Prata³  Marcos Vinicius GB da Silva³  Marco Antonio Machado³  Rui S Verneque³  Célio de Freitas³  Maria Gabriela CD Peixoto³  John Furlong³  Ana Luisa S Azevedo³  Roberto L Teodoro³  Luciana CA Regitano⁴  Luiz L Coutinho⁵ 

[1] Departamento de Genética e Evolução, Universidade Federal de São Carlos, Rodovia Washington Luiz km 235, 13565-905, São Carlos, SP, Brazil;Departamento de Zootecnia, Universidade Federal de Viçosa, Viçosa, MG, Brazil;Embrapa Gado de Leite, Juiz de Fora, MG, Brazil;Embrapa Pecuária Sudeste, São Carlos, SP, Brazil;Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, Piracicaba, SP, Brazil;

关键词: Quantitative Trait Locus;    Coat Color;    Polymorphic Information Content;    Total Phenotypic Variation;    Significant Quantitative Trait Locus;   

DOI  :  10.1186/1471-2164-11-280

 received in 2009-09-03, accepted in 2010-04-30,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIn tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) × Holstein (Bos taurus) cross.ResultsThrough a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23.ConclusionsThe experimental F2 population derived from Gyr × Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle.

【 授权许可】

CC BY   
© Machado et al; licensee BioMed Central Ltd. 2010