Prolonged survival of a patient with metastatic leptomeningeal melanoma treated with BRAF inhibition-based therapy: a case report

BMC Cancer

Case Report

Kevin B Kim¹  Dae Won Kim²  Edelyn Barcena²  Michelle L Rohlfs²  Urvi N Mehta²  Marta Penas-Prado³  Ashok J Kumar⁴ 

[1] California Pacific Medical Center for Melanoma Research and Treatment, San Francisco Oncology Associates, 2333 Buchanan St., 94115, San Francisco, CA, USA;Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;

关键词: Metastatic melanoma;    Leptomeningeal disease;    BRAF inhibitors;   

DOI  :  10.1186/s12885-015-1391-x

 received in 2014-06-22, accepted in 2015-04-29,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundLeptomeningeal metastasis of melanoma is a devastating complication with a grave prognosis, and there are no known effective standard treatments. Although selective BRAF inhibitors have demonstrated a significant clinical activity in patients with metastatic melanoma harboring a BRAF mutation, the clinical benefit of BRAF inhibitor-based therapy in leptomeningeal disease is not clear.Case presentationWe present a case of prolonged survival of a patient with BRAF V600E-mutant leptomeningeal disease who was treated with vemurafenib followed by whole brain radiation and a combination of dabrafenib and trametinib. Both vemurafenib and the sequential treatment of radiation and dabrafenib/trametinib led to regression of the leptomeningeal disease, and the patient survived for 19 months after the diagnosis of the leptomeningeal disease.ConclusionThis case suggests a possible clinically meaningful benefit of BRAF inhibitor-based therapy and a need for close investigation of this therapeutic approach in patients with this devastating disease.

【 授权许可】

CC BY   
© Kim et al.; licensee BioMed Central. 2015