Effects of Korean red ginseng (Panax Ginseng Meyer) on bisphenol A exposure and gynecologic complaints: single blind, randomized clinical trial of efficacy and safety

BMC Complementary and Alternative Medicine

Research Article

Min-Woo Hwang¹  Mirim Jin²  Mihi Yang³  Ho-Sun Lee³ 

[1] Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea;Labobatory of Pathology, College of Oriental Medicine, Daejeon University, Daejeon, Republic of Korea;Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women’s University, Hyochangwon-gil 52, 140-742, Yongsan-Gu, Seoul, Republic of Korea;

关键词: Korean red ginseng;    Bisphenol A;    Chemoprevention;    Sasang typology;    Gynecologic complaints;    Quality of life;   

DOI  :  10.1186/1472-6882-14-265

 received in 2013-10-20, accepted in 2014-07-14,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundKorean red ginseng (KRG) is a processed ginseng from raw ginseng to enhance safety, preservation and efficacy, known having beneficial effects on women’s health due to its estrogen like function. While estrogen supplementation showed some modulation of endocrine disrupting chemicals, bisphenol A (BPA) has been focused as a potential endocrine disrupting chemical. In this study, we examined the efficacy and safety outcomes of KRG against BPA, focusing on female quality of life (QOL). Individual variations in susceptibility to KRG were also investigated with the Sasang Typology, the personalized medicine used for hundred years in Korea.MethodsWe performed a single-blind randomized clinical trial. Study subjects were young women (N = 22), consumed 2.7 g of KRG or placebo per day for 2 weeks and filled up questionnaires regarding gynecologic complaints at the 4 time spots. We analyzed urinary total BPA and malondialdehyde (MDA), an oxidative stress biomarker, with GC/MS and HPLC/UVD respectively, and diagnosed their Sasang Typology with the questionnaire for the Sasang constitution Classification (QSCC II).ResultsKRG consumption decreased urinary BPA and MDA levels (ps < 0.05) and alleviated ‘menstrual irregularity’, ‘menstrual pain’, and ‘constipation’ (ps < 0.05). SoEum type (Lesser Yin person) among the Sasang types showed significant alleviation in insomnia, flushing, perspiration and appetite by KRG consumption, rather than other Sasang types. During the intervention, no one experienced any aggravated side effects.ConclusionWe suggest KRG is efficient for protection for female QOL and BPA- exposure and – related oxidative stress. However, individual variation in susceptibility to KRG should be further considered for identifying ideal therapy.Trial registrationKCT0000920.

【 授权许可】

CC BY   
© Yang et al.; licensee BioMed Central Ltd. 2014