Rates of pneumonia among children and adults with chronic medical conditions in Germany

BMC Infectious Diseases

Research Article

Kimberly M. Shea¹  Stephen I. Pelton²  David R. Strutton³  Raymond A. Farkouh³  Rogier Klok⁴  Elana S. Gruen⁵  Derek Weycker⁵  Christian Jacob⁶  Sebastian Braun⁶ 

[1] Boston University School of Public Health, Boston, MA, USA;Boston University School of Public Health, Boston, MA, USA;Boston Medical Center, Boston, MA, USA;Maxwell Finland Laboratory for Infectious Diseases, 670 Albany Street, 6th Floor, 02118, Boston, MA, USA;Pfizer Inc., Collegeville, PA, USA;Pfizer bv, Capelle a/d IJssel, Netherlands;Policy Analysis Inc. (PAI), Brookline, MA, USA;Xcenda GmbH, Hannover, Germany;

关键词: Streptococcus pneumoniae;    Pneumococcal infections;    Pneumonia;    Comorbidity;    Germany;   

DOI  :  10.1186/s12879-015-1162-y

 received in 2015-04-30, accepted in 2015-09-30,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe objective of this study is to evaluate rates of all-cause pneumonia among “at-risk” and “high-risk” children and adults in Germany—in comparison with age-stratified healthy counterparts—during the period following the 2006 recommendation for universal immunization of infants with pneumococcal conjugate vaccine.MethodsRetrospective cohort design and healthcare claims information for 3.4 M persons in Germany (2009–2012) were employed. Study population was stratified by age and risk profile (healthy, “at-risk” [with chronic medical conditions], and “high-risk” [immunocompromised]). At-risk and high-risk conditions, as well as episodes of all-cause pneumonia, were identified via diagnosis, procedure, and drug codes.Results and discussionRates of all-cause pneumonia were 1.7 (95 % CI 1.7-1.8) to 2.5 (2.4-2.5) times higher among children and adults with at-risk conditions versus healthy counterparts, and 1.8 (1.8-1.9) to 4.1 (4.0-4.2) times higher among children and adults with high-risk conditions. Rates of all-cause pneumonia among at-risk persons increased in a graded and monotonic fashion with increasing numbers of conditions (i.e., risk stacking).ConclusionsAn increased risk for all-cause pneumonia in German children and adults with a spectrum of medical conditions persists in the era of widespread pneumococcal vaccination, and pneumonia risk in persons with ≥2 at-risk conditions is comparable or higher than those with high-risk conditions.

【 授权许可】

CC BY   
© Pelton et al. 2015