Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients: a Danish population-based cohort study

BMC Surgery

Research Article

Rune Gärtner¹  Niels Kroman¹  Lars Pedersen²  Deirdre Cronin-Fenton²  Henrik Toft Sørensen²  Timothy L Lash³  Heidi H Hundborg⁴ 

[1] Department of Breast Surgery, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark;Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43-45, N 8200, Aarhus, Denmark;Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43-45, N 8200, Aarhus, Denmark;Department of Epidemiology, Boston University School of Public Health, 715 Albany St., 02118, Boston, MA, USA;Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43-45, N 8200, Aarhus, Denmark;National Centre for Register-based Research, University of Aarhus, Aarhus, Denmark;

关键词: Selective Serotonin Reuptake Inhibitor;    Lofepramine;    Opipramol;    Selective Serotonin Reuptake Inhibitor User;    Selective Serotonin Reuptake Inhibitor Medication;   

DOI  :  10.1186/1471-2482-10-3

 received in 2009-08-25, accepted in 2010-01-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundSelective serotonin reuptake inhibitors (SSRI) decrease platelet-function, which suggests that SSRI use may increase the risk of post-surgical bleeding. Few studies have investigated this potential association.MethodsWe conducted a population-based study of the risk of re-operation due to post-surgical bleeding within two weeks of primary surgery among Danish women with primary breast cancer. Patients were categorised according to their use of SSRI: never users, current users (SSRI prescription within 30 days of initial breast cancer surgery), and former users (SSRI prescription more than 30 days before initial breast cancer surgery). We calculated the risk of re-operation due to post-surgical bleeding within 14 days of initial surgery, and the relative risk (RR) of re-operation comparing SSRI users with never users of SSRI adjusting for potential confounders.Results389 of 14,464 women (2.7%) were re-operated. 1592 (11%) had a history of SSRI use. Risk of re-operation was 2.6% among never users, 7.0% among current SSRI users, and 2.7% among former users. Current users thus had an increased risk of re-operation due to post-operative bleeding (adjusted relative risk = 2.3; 95% confidence interval (CI) = 1.4, 3.9) compared with never users. There was no increased risk of re-operation associated with former use of SSRI (RR = 0.93, 95% CI = 0.66, 1.3).ConclusionsCurrent use of SSRI is associated with an increased risk of re-operation due to bleeding after surgery for breast cancer.

【 授权许可】

Unknown   
© Gärtner et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.