BMC Cancer | |
Clinicopathological factors influencing the outcomes of surgical treatment in patients with T4a hypopharyngeal cancer | |
Research Article | |
Joo-Hyun Woo1  Dong Hoon Lee2  Sang-Yeon Kim3  Min-Sik Kim3  Young-Hoon Joo4  Eun-Chang Choi5  Da-Hee Kim5  Min Woo Park6  Young-Soo Rho6  Eun Jae Chung7  | |
[1] Department of Otolaryngology Head and Neck Surgery, Gachon University Gil Hospital, Incheon, Korea;Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School & Chonnam National University Hwasun Hospital, Hwasun, Korea;Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Department of Otolaryngology, Head and Neck Surgery, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 2 Sosa-dong, Wonmi-gu, 420-717, Bucheon, Kyounggi-do, Republic of Korea;Department of Otorhinolaryngology, Yonsei University, College of Medicine, Seoul, Republic of Korea;Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, Republic of Korea;Department of Otorhinolaryngology–Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea; | |
关键词: Head and neck neoplasms; Hypopharynx; Squamous cell carcinoma; Surgery; Treatment outcome; | |
DOI : 10.1186/s12885-017-3880-6 | |
received in 2017-07-19, accepted in 2017-12-07, 发布年份 2017 | |
来源: Springer | |
【 摘 要 】
BackgroundThe purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer.MethodsThe present study enrolled 93 patients diagnosed with T4a hypopharyngeal cancer who underwent primary surgery between January 2005 and December 2015 at six medical centers in Korea. Primary tumor sites included pyriform sinus in 71 patients, posterior pharyngeal wall in 14 patients, and postcricoid region in 8 patients. Seventy-two patients received postoperative radio(chemo)therapy.ResultsFive-year disease-free survival (DFS) and disease-specific survival (DSS) rates were 38% and 45%, respectively. In univariate analysis, 5-year DFS was found to have significant and positive correlations with margin involvement (p < 0.001) and extracapsular spread (p = 0.025). Multivariate analysis confirmed that margin involvement (hazard ratio (HR): 2.81; 95% confidence interval (CI): 1.49-5.30; p = 0.001) and extracapsular spread (HR: 2.08; 95% CI: 1.08-3.99; p = 0.028) were significant factors associated with 5-year DFS. In univariate analysis, cervical lymph node metastasis (p = 0.048), lymphovascular invasion (p = 0.041), extracapsular spread (p = 0.015), and esophageal invasion (p = 0.033) were significant factors associated with 5-year DSS. In multivariate analysis, extracapsular spread (HR: 2.98; 95% CI: 1.39-6.42; p = 0.005) and esophageal invasion (HR: 2.87; 95% CI: 1.38-5.98; p = 0.005) remained significant factors associated with 5-year DSS.ConclusionMargin involvement and extracapsular spread are factors influencing recurrence while extracapsular spread and esophageal invasion are factors affecting survival in patients with T4a hypopharyngeal cancer treated by primary surgery.
【 授权许可】
CC BY
© The Author(s). 2017
【 预 览 】
Files | Size | Format | View |
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RO202311095808586ZK.pdf | 799KB | download |
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