Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

BMC Gastroenterology

Research Article

Victor Moreno¹  Daniele Campa²  Stefano Landi²  Federica Gemignani²  Marco Antinucci²  Sergio Tofanelli²  Roberto Marangoni²  Massimo Dal Monte²  Maurizio Cammalleri²  Roberto Barale²  Jonathan Barontini²  Juozas Kupcinskas³  Veronika Vymetalkova⁴  Pavel Vodicka⁵  Ludmila Vodickova⁵  Anna Panza⁶  Nicola Mastrodonato⁶  Francesca Tavano⁶  Angelika Stein⁷  Federico Canzian⁷  Asta Forsti⁸ 

[1] Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), IDIBELL, CIBERESP and Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain;Department of Biology, University of Pisa, Via Derna 1, 56100, Pisa, Italy;Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania;Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Prague, Czech Republic;Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic;Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Prague, Czech Republic;Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic;Biomedical Centre, Medical School Pilsen, Charles University in Prague, Pilsen, Czech Republic;Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy;Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany;Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany;

关键词: Taste receptors;    TAS2R16;    Polymorphisms;    Colon cancer;    Rectal cancer;    Colorectal cancer;    Cancer risk;    Genetic association study;   

DOI  :  10.1186/s12876-017-0659-9

 received in 2017-04-26, accepted in 2017-08-29,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundGenetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1‑4% of CRC heritability, highlighting the dire need of identifying novel risk loci. In this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin, a natural antipyretic that resembles aspirin. Given the importance of inflammation in CRC, we tested whether polymorphic variants in this gene could affect the risk of developing this neoplasia hypothesizing a role of TAS2R16 in modulating chronic inflammation within the gut.MethodsWe performed an association study using 6 tagging SNPs, (rs860170, rs978739, rs1357949, rs1525489, rs6466849, rs10268496) that cover all TAS2R16 genetic variability. The study was carried out on 1902 CRC cases and 1532 control individuals from four European countries.ResultsWe did not find any statistically significant association between risk of developing CRC and selected SNPs. However, after stratification by histology (colon vs. rectum) we found that rs1525489 was associated with increased risk of rectal cancer with a (Ptrend of = 0.0071).ConclusionsOur data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts.

【 授权许可】

CC BY   
© The Author(s). 2017