Ziziphi spinosae lily powder suspension in the treatment of depression-like behaviors in rats

BMC Complementary and Alternative Medicine

Research Article

Jinyong Xu¹  Xinyi Lu²  Runze Wei²  Mei Huang²  Yifang Wang² 

[1] High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230031, Hefei, People’s Republic of China;University of Science and Technology of China, 230022, Hefei, People’s Republic of China;Department of Anatomy, Anhui Medical University, 230032, Hefei, People’s Republic of China;The first clinical college, Anhui Medical University, 230032, Hefei, People’s Republic of China;

关键词: Semen ziziphi spinosae;    Lily bulb;    Major depressive disorder;    Antidepressant;    5-HT;    5-HIAA;   

DOI  :  10.1186/s12906-017-1749-5

 received in 2017-01-14, accepted in 2017-04-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDepression is a chronic, recurring and potentially life-threatening illness. Current treatments for depression are characterized by a low success rate and associated with a wide variety of side effects. The aim of the present study was to evaluate the behavioral anti-depressant effect of a novel herbal compounds named ziziphi spinosae lily powder suspension, as well as to investigate its potential mechanisms.MethodsExcept for body weight, depressive-like behaviors were also evaluated using forced swimming test, sucrose consumption test and open field test. In order to investigate the underlying potential mechanisms, serum 5-HT and brain 5-HIAA were measured using ultrahigh-performance liquid chromatography and high-performance liquid chromatography, respectively.ResultsResults showed that the herbal compounds ziziphi spinosae lily suspension could alleviate depressive symptoms in rat model of chronic depression. Biochemical analysis revealed that the herbal compounds elevated serum 5-HT and brain 5-HIAA.ConclusionZiziphi spinosae lily powder suspension could alleviate depressive behaviors in depression model animals. The underlying mechanisms may be related to the increase of serum 5-HT in peripheral blood and 5-HIAA in brain. The study provides important mechanistic insights into the protective effect of the herbal compounds against chronic depressive disorder and suggests that the herbal compounds may be a potential pharmacological agent for treatment of major depressive disorder.

【 授权许可】

CC BY   
© The Author(s). 2017