A prospective study of dietary selenium intake and risk of type 2 diabetes

BMC Public Health

Research Article

Marco Vinceti¹  Martin Laclaustra²  Eliseo Guallar²  Paola Muti³  Franco Berrino⁴  Saverio Stranges⁵  Vittorio Krogh⁶  Sabina Sieri⁶  Sara Grioni⁶ 

[1] Department of Public Health Sciences, University of Modena and Reggio Emilia, Modena, Italy;Departments of Epidemiology and Medicine, and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;Department of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Research (CNIC), Madrid, Spain;Epidemiology and Prevention Unit, "Regina Elena" Italian National Cancer Institute, Rome, Italy;Etiological and Preventive Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;Health Sciences Research Institute, University of Warwick Medical School, Coventry, UK;Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;

关键词: Selenium;    Diabetes Risk;    Serum Selenium;    Selenium Content;    Selenium Status;   

DOI  :  10.1186/1471-2458-10-564

 received in 2010-05-21, accepted in 2010-09-21,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundGrowing evidence raises concern about possible associations of high selenium exposure with diabetes in selenium-replete populations such as the US. In countries with lower selenium status, such as Italy, there is little epidemiological evidence on the association between selenium and diabetes. This study examined the prospective association between dietary selenium intake and risk of type 2 diabetes.MethodsThe ORDET cohort study comprised a large sample of women from Northern Italy (n = 7,182). Incident type 2 diabetes was defined as a self-report of a physician diagnosis, use of antidiabetic medication, or a hospitalization discharge. Dietary selenium intake was measured by a semi-quantitative food-frequency questionnaire at the baseline examination (1987-1992). Participants were divided in quintiles based on their baseline dietary selenium intake.ResultsAverage selenium intake at baseline was 55.7 μg/day. After a median follow-up of 16 years, 253 women developed diabetes. In multivariate logistic regression analyses, the odds ratio for diabetes comparing the highest to the lowest quintile of selenium intake was 2.39, (95% CI: 1.32, 4.32; P for linear trend = 0.005). The odds ratio for diabetes associated with a 10 μg/d increase in selenium intake was 1.29 (95% CI: 1.10, 1.52).ConclusionsIn this population, increased dietary selenium intake was associated with an increased risk of type 2 diabetes. These findings raise additional concerns about the association of selenium intake above the Recommended Dietary Allowance (55 μg/day) with diabetes risk.

【 授权许可】

CC BY   
© Stranges et al; licensee BioMed Central Ltd. 2010