Study protocol of KLIMOP: a cohort study on the wellbeing of older cancer patients in Belgium and the Netherlands

BMC Public Health

Study Protocol

Loes Linsen¹  Daan Walgraeve²  Bert Houben³  Alexander Goegebuer⁴  Hans Wildiers⁵  Liesbeth Daniels⁶  Laura Deckx⁶  Frank Buntinx⁷  Marjan van den Akker⁷  Eric T de Jonge⁸  Franchette van den Berkmortel⁹  Doris van Abbema^1,10  Vivianne C Tjan-Heijnen^1,10  Jolanda Verheezen^1,11  Luc Spaas^1,12  Karin Pat^1,13  Thessa Verniest^1,14  Piet Stinissen^1,15  Katherine Nelissen^1,15  Jean-Luc Rummens^1,16  Geert Robaeys^1,17  Paul Bulens^1,18 

[1] Biobank and Clinical Laboratory of Experimental Hematology, Jessa Hospital - campus Virga Jesse, Stadsomvaart 11, 3500, Hasselt, Belgium;Department of Gastroenterology, Jessa Hospital - campus Salvator, Salvatorstraat 20, 3500, Hasselt, Belgium;Department of Gastroenterology, Jessa Hospital - campus Virga Jesse, Stadsomvaart 11, 3500, Hasselt, Belgium;Department of Gastroenterology, Regionaal Ziekenhuis Heilig Hart Leuven, Naamsestraat 105, 3000, Leuven, Belgium;Department of General Medical Oncology, University Hospitals Leuven, Campus Gasthuisberg, 3000, Herestraat 49, Leuven, Belgium;Department of General Practice, Katholieke Universiteit Leuven, bus 7001, Kapucijnenvoer 33, 3000, Leuven, Belgium;Department of General Practice, Katholieke Universiteit Leuven, bus 7001, Kapucijnenvoer 33, 3000, Leuven, Belgium;Department of General Practice, Maastricht University, CAPHRI - School for Public Health and Primary Care, P.O. Box 616, Peter Debeyeplein 1, 6200 MD, Maastricht, The Netherlands;Department of Gynaecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium;Department of Internal Medicine, Atrium Medical Centre Parkstad, P.O. Box 4446, Henri Dunantstraat 5, 6401 CX, Heerlen, The Netherlands;Department of Medical Oncology, Maastricht University Medical Centre, GROW - School for Oncology and Developmental Biology, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands;Department of Medical Oncology, Regionaal Ziekenhuis Sint-Trudo, Diestersteenweg 100, 3800, Sint-Truiden, Belgium;Department of Pulmonology, Jessa Hospital - campus Salvator, Salvatorstraat 20, 3500, Hasselt, Belgium;Department of Pulmonology, Jessa Hospital - campus Virga Jesse, Stadsomvaart 11, 3500, Hasselt, Belgium;Department of Pulmonology, Regionaal Ziekenhuis Heilig Hart Leuven, Naamsestraat 105, 3000, Leuven, Belgium;Faculty of Medicine, Hasselt University, Campus Diepenbeek, Agoralaan building A, 3590, Diepenbeek, Belgium;Faculty of Medicine, Hasselt University, Campus Diepenbeek, Agoralaan building A, 3590, Diepenbeek, Belgium;Biobank and Clinical Laboratory of Experimental Hematology, Jessa Hospital - campus Virga Jesse, Stadsomvaart 11, 3500, Hasselt, Belgium;Faculty of Medicine, Hasselt University, Campus Diepenbeek, Agoralaan building A, 3590, Diepenbeek, Belgium;Department of Gastroenterology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium;Limburgs Oncologisch Centrum, Stadsomvaart 11, 3500, Hasselt, Belgium;

关键词: Cancer Patient;    Telomere Length;    Comprehensive Geriatric Assessment;    Buccal Swab;    Loneliness Scale;   

DOI  :  10.1186/1471-2458-11-825

 received in 2011-10-03, accepted in 2011-10-25,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCancer is mainly a disease of older patients. In older cancer patients, additional endpoints such as quality of survival and daily functioning might be considered equally relevant as overall or disease free survival. However, these factors have been understudied using prospective designs focussing on older cancer patients. Therefore, this study will focus on the impact of cancer, ageing, and their interaction on the long-term wellbeing of older cancer patients.Methods/DesignThis study is an observational cohort study. We aim to recruit 720 cancer patients above 70 years with a new diagnosis of breast, prostate, lung or gastrointestinal cancer and two control groups: one control group of 720 patients above 70 years without a previous diagnosis of cancer and one control group of 720 cancer patients between 50 - 69 years newly diagnosed with breast, prostate, lung or gastrointestinal cancer. Data collection will take place at inclusion, after six months, after one year and every subsequent year until death or end of the study. Data will be collected through personal interviews (consisting of socio-demographic information, general health information, a comprehensive geriatric assessment, quality of life, health locus of control and a loneliness scale), a handgrip test, assessment of medical records, two buccal swabs and a blood sample from cancer patients (at baseline). As an annex study, caregivers of the participants will be recruited as well. Data collection for caregivers will consist of a self-administered questionnaire examining depression, coping, and burden.DiscussionThis extensive data collection will increase insight on how wellbeing of older cancer patients is affected by cancer (diagnosis and treatment), ageing, and their interaction. Results may provide new insights, which might contribute to the improvement of care for older cancer patients.

【 授权许可】

CC BY   
© Deckx et al; licensee BioMed Central Ltd. 2011