Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan

BMC Gastroenterology

Research Article

Mitsuhiro Fujishiro¹  Nobutake Yamamichi¹  Yoshiki Sakaguchi¹  Satoshi Ono¹  Yoshizumi Shintani¹  Kazuya Okushin¹  Hidetaka Fujinaga¹  Shinya Kodashima¹  Hiroshi Yotsuyanagi¹  Yu Takahashi¹  Kazuhiko Koike¹  Kyoji Moriya¹  Takeya Tsutsumi¹  Kenichiro Enooku¹  Takeshi Shimamoto²  Toru Mitsushima² 

[1] Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;Kameda Medical Center Makuhari (CD-2, 1–3, Nakase, Mihama-ku, Chiba-city, Japan;

关键词: Fatty liver disease;    NAFLD;    Metabolic syndrome;    Helicobacter pylori;   

DOI  :  10.1186/s12876-015-0247-9

 received in 2015-01-19, accepted in 2015-02-02,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundFatty liver disease (FLD) including non-alcoholic fatty liver disease (NAFLD), a rapidly emerging and widely recognized liver disease today, is regarded as a hepatic manifestation of metabolic syndrome. Helicobacter pylori, one of the most common pathogens worldwide, has been reported to be associated with metabolic syndrome, but whether there is a direct association with FLD is as of yet unclear. The aim of this study was to clarify the association of FLD and NAFLD with causative background factors including Helicobacter pylori infection.MethodsThis was a cross-sectional study of Japanese adults who received medical checkups at a single medical center in 2010.Univariate and multivariate statistical analysis was performed to evaluate background factors for ultrasonography diagnosed FLD. Subjects free from alcohol influence were similarly analyzed for NAFLD.ResultsOf a total of 13,737 subjects, FLD was detected in 1,456 of 6,318 females (23.0 %) and 3,498 of 7,419 males (47.1%). Multivariable analyses revealed that body mass index (standardized coefficients of females and males (β-F/M) =143.5/102.5), serum ALT (β-F/M = 25.8/75.7), age (β-F/M = 34.3/17.2), and platelet count (β-F/M = 17.8/15.2) were positively associated with FLD in both genders. Of the 5,289 subjects free from alcohol influence, NAFLD was detected in 881 of 3,473 females (25.4%) and 921 of 1,816 males (50.7%). Body mass index (β-F/M = 113.3/55.3), serum ALT (β-F/M = 21.6/53.8), and platelet count (β-F/M = 13.8/11.8) were positively associated with NAFLD in both genders. Metabolic syndrome was positively associated with FLD and NAFLD only in males. In contrast, Helicobacter pylori infection status was neither associated with FLD nor NAFLD regardless of gender.ConclusionsBody mass index, serum ALT and platelet count were significantly associated with FLD and NAFLD, whereas infection of Helicobacter pylori was not.

【 授权许可】

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© Okushin et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.