Fecal calprotectin levels are higher in rural than in urban Chinese infants and negatively associated with growth

BMC Pediatrics

Research Article

Xiao-Gang Yu¹  Xiao-Yang Sheng¹  Jin-Rong Liu¹  Yan-Qi Hu¹  K Michael Hambidge²  Nancy F Krebs²  Jamie E Westcott²  Leland V Miller² 

[1] Department of Child and Adolescent Health Care, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Institute for Pediatric Research, 1665 Kongjiang Road, 200092, Shanghai, China;Department of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Box C225, Research Complex II, 12700 East 19th Avenue, 80045, Aurora, CO, USA;

关键词: Fecal calprotectin;    Infants;    Children;    Gut inflammation;    Growth;   

DOI  :  10.1186/1471-2431-12-129

 received in 2012-01-26, accepted in 2012-08-16,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundFecal calprotectin (FC) is an established simple biomarker of gut inflammation. To examine a possible relationship between linear growth and gut inflammation, we compared fecal calprotectin levels in 6 month old infants from poor rural vs affluent urban families.MethodsThe project was a cross-sectional comparison of FC from rural and urban populations in China. The relationship between length-for-age Z-score (LAZ) and FC concentrations were also compared. Single fecal samples were assayed for FC using EK-CAL ELISA kits.ResultsThe age of subjects for both locations was 6.1 ± 0.2 mo; all were apparently healthy. The mean ± SD of the LAZ for the rural and urban infants were −0.6 ± 0.9 and 0.4 ± 0.9, respectively. FC had a non-normal distribution. The median FC of 420.9 and 140.1 μg/g for rural and urban infants, respectively, were significantly different (P < 0.0001). For the rural group, linear regression analysis showed that an increase in FC of 100 μg/g was associated with a decrease of 0.06 in LAZ.ConclusionFC levels were significantly elevated in the rural infants and high concentrations accounted for approximately one-third of the low LAZ scores of these infants.

【 授权许可】

Unknown   
© Liu et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.