Case report - atypical hemolytic uremic syndrome triggered by influenza B

BMC Nephrology

Case Report

Martin Christner¹  Markus J. Kemper¹  Robin Kobbe¹  Raphael Schild¹  Sebastian Loos¹  Jun Oh¹ 

[1] University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany;

关键词: Influenza;    Hemolytic uremic syndrome;    HUS;    Atypical HUS;    aHUS;    Influenza vaccination;    Quadrivalent;   

DOI  :  10.1186/s12882-017-0512-y

 received in 2016-02-25, accepted in 2017-03-15,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundInfluenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.Case presentationA 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.ConclusionInfluenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.

【 授权许可】

CC BY   
© The Author(s). 2017