Evolutionary analysis of the ENTH/ANTH/VHS protein superfamily reveals a coevolution between membrane trafficking and metabolism

BMC Genomics

Research Article

Sylvie Friant¹  Johan-Owen De Craene¹  Raymond Ripp²  Olivier Poch²  Odile Lecompte²  Julie D Thompson² 

[1] Department of Molecular and Cellular Genetics, UMR7156 CNRS/Université de Strasbourg, 21 rue Descartes, 67084, Strasbourg, France;Integrative Bioinformatics and Genomics, Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC (CNRS/INSERM/UdS), 1 rue Laurent Fries, 67404, Illkirch, France;

关键词: Membrane trafficking;    Cytokinesis;    Metabolism;    Comparative genomic;    Eukaryotic evolution;    Phylogeny;   

DOI  :  10.1186/1471-2164-13-297

 received in 2011-12-20, accepted in 2012-06-22,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundMembrane trafficking involves the complex regulation of proteins and lipids intracellular localization and is required for metabolic uptake, cell growth and development. Different trafficking pathways passing through the endosomes are coordinated by the ENTH/ANTH/VHS adaptor protein superfamily. The endosomes are crucial for eukaryotes since the acquisition of the endomembrane system was a central process in eukaryogenesis.ResultsOur in silico analysis of this ENTH/ANTH/VHS superfamily, consisting of proteins gathered from 84 complete genomes representative of the different eukaryotic taxa, revealed that genomic distribution of this superfamily allows to discriminate Fungi and Metazoa from Plantae and Protists. Next, in a four way genome wide comparison, we showed that this discriminative feature is observed not only for other membrane trafficking effectors, but also for proteins involved in metabolism and in cytokinesis, suggesting that metabolism, cytokinesis and intracellular trafficking pathways co-evolved. Moreover, some of the proteins identified were implicated in multiple functions, in either trafficking and metabolism or trafficking and cytokinesis, suggesting that membrane trafficking is central to this co-evolution process.ConclusionsOur study suggests that membrane trafficking and compartmentalization were not only key features for the emergence of eukaryotic cells but also drove the separation of the eukaryotes in the different taxa.

【 授权许可】

Unknown   
© De Craene et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.