Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study

BMC Ophthalmology

Research Article

Loraine L. W. Chow¹  Kendrick C. Shih²  Jimmy S. M. Lai²  Alex L. K. Ng²  Johnny C. Y. Chan³ 

[1] Department of Ophthalmology, Queen Mary Hospital, Hospital Authority, Pok Fu Lam, Hong Kong;Department of Ophthalmology, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Pok Fu Lam, Hong Kong;Division of Dermatology, Department of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong;

关键词: Ocular surface disease;    Severe cutaneous adverse reactions;    Stevens-Johnson syndrome;    Toxic epidermal necrolysis;    Asians;   

DOI  :  10.1186/s12886-017-0464-9

 received in 2016-03-31, accepted in 2017-05-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN.MethodsThe initial presenting ophthalmic records of patients with either SJS (<30% body surface area involvement) or TEN (> = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared.ResultsA total of 20 SJS and 12 TEN cases were included. All were drug-induced. The patient demographics and treatment received were comparable. Overall, 40% of SJS and 75% of TEN patients had acute ocular surface inflammation. When comparing the two groups, there was a significant difference in the number of cases with mild involvement (5% in SJS, 42% in TEN, p = 0.01), while no statistically significant differences were found (p > 0.05) comparing between the moderate (15% in SJS, 0% in TEN) and severe groups (20% in SJS, 33% in TEN).ConclusionsOcular surface inflammation was common during the acute phase in both SJS and TEN. TEN had a significantly higher number of cases with mild ocular involvement when compared with SJS, but no significant difference between the number of moderate and severe cases between the two groups.

【 授权许可】

CC BY   
© The Author(s). 2017