Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults

BMC Ophthalmology

Research Article

Yan Zhang¹  Jianping Li¹  Yong Huo¹  Wenbin Yang²  Rongfeng Liao³  Xiaopeng Gu⁴  Xuling Chen⁴  Kun Shang⁴  Ying Meng⁴  Yuan Peng⁴  Yadi Zhang⁴  Liang Zhao⁴  Jing Zhang⁴  Liu Yang⁴  Jun Li⁴  Hiacheng She⁵  Binyan Wang⁶  Xianhui Qin⁶  Xiping Xu⁶  Fanfan Hou⁶  Genfu Tang⁷ 

[1] Department of Cardiology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, 100034, Beijing, China;Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 230032, Hefei, Anhui, China;Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 230032, Hefei, Anhui, China;Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, 230032, Hefei, Anhui, China;Department of Ophthalmology, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, 100034, Beijing, China;Department of Tongren Hospital, 100005, Beijing, China;National Clinical Research Study Center for Kidney Disease; State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China;School of Health Administration, Anhui University, 230039, Hefei, China;

关键词: Serum Uric Acid Concentration;    Hypertensive Retinopathy;    Hypertension;    Hyperuricemia;    Keith-Wagener-Barker system;   

DOI  :  10.1186/s12886-017-0470-y

 received in 2017-02-09, accepted in 2017-05-15,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThis cross sectional investigation included 12,966 subjects with hypertension, a cohort of the China Stroke Primary Prevention Trial (CSPPT), a randomized, multicenter clinical trial. This study aimed to explore the correlation between serum uric acid (SUA) concentration and hypertensive retinopathy in hypertensive adults.MethodsDiagnosis of hypertensive retinopathy was determined by non-mydriatic fundus photography and classified with Keith-Wagener-Barker (KWB) system. The correlation of SUA levels with hypertensive retinopathy prevalence and severity was assessed by statistical analysis.Results9848 (75.95%) subjects were diagnosed with hypertensive retinopathy with the following retinopathy grade distribution: grade 1: 58.80%, grade 2: 14.81%, and grade 3–4: 2.34%. SUA levels were significantly associated with hypertensive retinopathy prevalence. Patients with hypertensive retinopathy had higher SUA levels than those without hypertensive retinopathy. Patients in the highest uric acid quartile had an odds ratio for hypertensive retinopathy of 1.21 compared to patients in the lowest uric acid quartile (OR = 1.21, 95% CI: 1.05–1.40, P = 0.008). When compared to the non-hyperuricemia group, those in the hyperuricemia group had an odds ratio for hypertensive retinopathy of 1.18(OR = 1.18, 95% CI: 1.05–1.33, P = 0.004). Every 1 mg/dl increase in uric acid concentration was significantly associated with a 6% higher odds of hypertensive retinopathy (OR = 1.06, 95% CI: 1.02–1.10, P = 0.002).ConclusionsThe prevalence of hypertensive retinopathy was high (75.95%) among hypertensives in our patients cohort. In addition, SUA concentration was significantly associated with hypertensive retinopathy.

【 授权许可】

CC BY   
© The Author(s). 2017