Risk of chronic liver disease in post-menopausal women due to body mass index, alcohol and their interaction: a prospective nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

BMC Public Health

Research Article

Usha Menon¹  Sophia Apostolidou¹  Andy Ryan¹  Matthew Burnell¹  Aleksandra Gentry-Maharaj¹  Ian Jacobs²  Paul M Trembling³  William M. Rosenberg³  Sudeep Tanwar³  Julie Parkes⁴ 

[1] Gynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, UK;Gynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, UK;Office of the President and Vice-Chancellor, The University of New South Wales, UNSW Sydney, Sydney, Australia;Institute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Hospital, Rowland Hill Street, NW3 2PF, London, UK;Public Health Sciences and Medical Statistics, Faculty of Medicine, University of Southampton, Southampton, UK;

关键词: Chronic liver disease;    Cirrhosis;    Alcohol;    Body mass index;    Obesity;   

DOI  :  10.1186/s12889-017-4518-y

 received in 2016-10-19, accepted in 2017-06-20,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWe investigated the risk of chronic liver disease (CLD) due to alcohol consumption and body mass index (BMI) and the effects of their interaction in a prospective cohort study of women recruited to the UKCTOCS trial.Methods95,126 post-menopausal women without documented CLD were stratified into 12 groups defined by combinations of BMI (normal, overweight, obese) and alcohol consumption (none, <1–15, 16–20 and ≥21 units/week), and followed for an average of 5.1 years. Hazard ratios (HR) were calculated for incident liver-related events (LRE).ResultsFirst LREs were reported in 325 (0.34%) participants. Compared to women with normal BMI, HR = 1.44 (95% CI; 1.10–1.87) in the overweight group and HR = 2.25 (95% CI; 1.70–2.97) in the obese group, adjusted for alcohol and potential confounders. Compared to those abstinent from alcohol, HR = 0.70 (95% CI; 0.55–0.88) for <1–15 units/week, 0.93 (95% CI; 0.50–1.73) for 16–20 units/week and 1.82 (95% CI; 0.97–3.39) for ≥21 units/week adjusted for BMI and potential confounders. Compared to women with normal BMI drinking no alcohol, HR for LRE in obese women consuming ≥21 units/week was 2.86 (95% CI; 0.67–12.42), 1.58 (95% CI; 0.96–2.61) for obese women drinking <1–15 units/week and 1.93 (95% CI; 0.66–5.62) in those with normal BMI consuming ≥21 units/week after adjustment for potential confounders. We found no significant interaction between BMI and alcohol.ConclusionHigh BMI and alcohol consumption and abstinence are risk factors for CLD in post-menopausal women. However, BMI and alcohol do not demonstrate significant interaction in this group.Trial registrationUKCTOCS is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978. Registered 06/04/2000.

【 授权许可】

CC BY   
© The Author(s). 2017